{"paper_id":"99d6786f-f1ba-4215-9505-10048e34b62b","body_text":"Abstract—\nConcentrations of eight different cytokines and the level of CD86 and CD163 expression by macrophages were studied in the peritoneal fluid of women with endometriosis. The concentration of both pro-inflammatory (IL-6, IL-8, TNF-α) and anti-inflammatory cytokines (IL-4) as well as the level of macrophage expression of the proinflammatory marker CD86 and anti-inflammatory marker CD163 increased in women with mild external genital endometriosis (stage 1−2), and did not differ from the control group in women with severe endometriosis (3−4 stage). The content of IL-2, IL-10, CM-CSF and IFN-γ in the peritoneal fluid of women with endometriosis insignificantly differed from the control group. 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Before collecting the biological material, all women signed an informed consent to participate in this clinical study.\nThe authors declare that they have no conflict of interest.\nAdditional information\nTranslated by A. Medvedev\nRights and permissions\nAbout this article\nCite this article\nKrasnyi, A.M., Sadekova, A.A., Sefihanov, T.G. et al. The Content of Cytokines IL-6, IL-8, TNF-α, IL-4 and the Level of CD86 and CD163 Expression in Peritoneal Fluid Macrophages Has a Reverse Correlation with the Degree of Severity of External Genital Endometriosis. Biochem. Moscow Suppl. Ser. B 14, 52–56 (2020). https://doi.org/10.1134/S1990750820010096\nReceived:\nRevised:\nAccepted:\nPublished:\nVersion of record:\nIssue date:\nDOI: https://doi.org/10.1134/S1990750820010096","source_license":"CC0","license_restricted":false}