{"paper_id":"9888bee0-776a-4310-872e-486172771617","body_text":"1. To understand the role of FDG PET/CT imaging in the multimodality investigation of gynecological and genitourinary cancers.\n2. To describe the mechanism of action and technical pitfalls of FDG-PET/CT.\n3. To highlight key imaging features of physiological and non-physiological FDG uptake and show how this is essential for interpretation of gynecological and genitourinary FDG-PET/CT studies.\n4. to review the pathophysiological mechanisms leading to potentially false-positive and false-negative assessments.\n\nIntroduction of FDG-PET/CT\n∘ Mechanism of action\n∘ Role in gynecological and genitourinary oncological imaging\n∘ FDG-PET/CT imaging protocols\nFalse positives in gynecological and genitourinary oncological imaging:\n∘ Physiological FDG-PET uptake – pictorial examples of uptake in endometrium and ovaries\n∘ Non-physiological FDG-PET uptake – pictorial examples of pelvic inflammatory disease, fibroids, endometriosis\nFalse negatives in gynecological and genitourinary oncological imaging:\n∘ Physiological FDG-PET uptake – pictorial examples of urinary excretion masking malignant lesions\n∘ No/low FDG uptake – pictorial examples of necrotic lymphadenopathy and low grade tumours\n∘ Artefacts\nPearls explaining how to minimise false interpretation\n\nFDG-PET/CT has a useful role in gynecological and genitourinary oncological imaging. However, understanding of physiological and non-physiological FDG- PET uptake is vital to understand potential false positive and false negatives in interpretation.\nFDG PET/CT should be used as one part of the multimodality investigation of gynecological and genitourinary cancers.","source_license":"CC-BY-4.0","license_restricted":false}