{"paper_id":"986b1f47-a83d-474f-ba65-4b7db143b289","body_text":"Critical Reviews™ in Eukaryotic Gene Expression\nPublished 8 issues per year\nISSN Print: 1045-4403\nISSN Online: 2162-6502\nResearch Article\nGlycosaminoglycan Adenogenesis Factors: Immunohistochemical Expression in Endometriosis Tissues Compared with the Endometrium\nABSTRACT\nEndometriosis is a chronic inflammatory pathology estrogen-dependent. It is a condition affecting 5%−10% of women of reproductive age worldwide. Recent evidence indicating an embryological origin of endometriosis has provided new insights into its pathogenesis and potential therapeutic approaches. In this study, we compared the immunohistochemical expression of extracellular matrix molecules involved in the interaction between epithelium and stroma in endometriotic lesions and normal endometrial tissue. A total of 41 cases were analyzed. We examined the immunohistochemical expression of chondroitin sulfate proteoglycan 4 (CSPG4), keratan sulfate, chondroitin sulfate (CS-56), hyaluronic acid, and heparan sulfate (HEP). Our results showed higher expression of CSPG4 and CS-56 in epithelial endometriosis samples compared with normal endometrial tissue, while HEP, keratan sulfate, and hyaluronic acid showed decreased expression in epithelial endometriosis samples relative to normal endometrial tissue. Additionally, endometriotic stroma exhibited more frequent low intensity of hyaluronic acid and HEP compared with normal endometrial stroma. Investigating the levels of these molecules in eutopic and ectopic endometrial tissues enables the identification of potential therapeutic targets, and the development of novel treatments aimed at disrupting the adhesive and invasive properties of endometriotic lesions.\nFigures\n-\nGray CA, Bartol FF, Tarleton BJ, Wiley AA, Johnson GA, Bazer FW, Spencer TE. Developmental biology of uterine glands. Biol Reprod. 2001;65:1311-23.\n-\nHabiba M, Heyn R, Bianchi P, Brosens I, Benagiano G. The development of the human uterus: Morphogenesis to menarche. Hum Reprod Update. 2021;27:1-26.\n-\nTaylor HS. The role of EMX2 in uterine development. Fertil Steril. 2015;103:633-4.\n-\nAcien P. Incidence of Mullerian defects in fertile and infertile women. Human Reprod. 1997;12:1372-6.\n-\nDietrich JE, Millar DM, Quint EH. Obstructive reproductive tract anomalies. J Pediatr Adolesc Gynecol. 2014;27:396-402.\n-\nChan YY, Jayaprakasan K, Zamora J, Thornton JG, Raine-Fenning N, Coomarasamy A. The prevalence of congenital uterine anomalies in unselected and high-risk populations: A systematic review. Hum Reprod Update. 2011;17:761-71.\n-\nPitot MA, Bookwalter CA, Dudiak KM. Müllerian duct anomalies coincident with endometriosis: A review. Abdom Radiol. 2020;45:1723-40.\n-\nPiriyev E, Römer T. Coincidence of uterine malformations and endometriosis: A clinically relevant problem? Arch Gynecol Obstet. 2020;302:1237-41.\n-\nBulun SE, Yilmaz BD, Sison C, Miyazaki K, Bernardi L, Liu S, Kohlmeier A, Yin P, Milad M, Wei J. Endometriosis. Endocr Rev. 2019;40:1048-79.\n-\nSignorile PG, Campioni M, Vincenzi B, D'Avino A, Baldi A. Rectovaginal septum endometriosis: An immunohistochemical analysis of 62 cases. In Vivo. 2009;23:459-64.\n-\nSignorile PG, Cassano M, Viceconte R, Spyrou M, Marcattilj V, Baldi A. Endometriosis: A retrospective analysis on diagnostic data in a cohort of 4401 patients. In Vivo. 2022;36:430-8.\n-\nSignorile PG., Cassano M, Viceconte R, Spyrou M, Marcattilj V, Baldi A. Endometriosis: A retrospective analysis of clinical data in a cohort of 4,083 patients, with focus on symptoms. In Vivo. 2022;36:874-83.\n-\nGiudice LC, Khao LC. Endometriosis. Lancet. 2004;364:1789-99.\n-\nSignorile PG, Baldi A. New evidences in endometriosis. Int J Biochem Cell Biol. 2015;60:19-22.\n-\nSignorile PG, Baldi F, Bussani R, D'Armiento M, De Falco M, Baldi A. Ectopic endometrium in human foetuses is a common event and sustains the theory of müllerianosis in the pathogenesis of endometriosis, a disease that predisposes to cancer. J Exp Clin Cancer Res. 2009;28:49.\n-\nSignorile PG, Baldi F, Bussani R, Viceconte R, Bulzomi P, D'Armiento M, D'Avino A, Baldi A. Embryologic origin of endometriosis: Analysis of 101 human female fetuses. J Cell Physiol. 2012;227:1653-6.\n-\nBouquet de Jolinière J, Ayoubi JM, Lesec G, Validire P, Goguin A, Gianaroli L, Dubuisson JB, Feki A,Gogusev J. Identification of displaced endometrial glands and embryonic duct remnants in female fetal reproductive tract: Possible pathogenetic role in endometriotic and pelvic neoplastic processes. Front Physiol. 2012;3:444.\n-\nSignorile PG, Viceconte R, Baldi A. New insights in pathogenesis of endometriosis. Front Med. 2022;9:879015.\n-\nSignorile PG, Baldi A, Viceconte R, Vincenzi B, Montella M. Adenogenesis factors FGF7, FGF10, FGF23, IFN-tau and HGF in endometriosis tissue respect to eutopic endometrium: An immunohistochemical study. Crit Rev Eukaryot Gene Expr. 2023;33:85-94.\n-\nSignorile PG, Viceconte R, Vincenzi B, Baldi A. Differential expression in endometriosis tissue versus endometrium of the uterine adenogenesis factors PRL-R, GH, IGF1, and IGF2. Crit Rev Eukaryot Gene Expr. 2023;33:39-46.\n-\nTaylor HS, Kotlyar AM, Flores VA. Endometriosis is a chronic systemic disease: Clinical challenges and novel innovations. Lancet. 2021;397:839-52.\n-\nSampson JA. Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavity. Am J Obstet Gynecol. 1927;14:422-69.\n-\nSignorile PG, Viceconte R, Vincenzi B, Baldi A. Differential expression in endometriosis tissue versus endometrium of the uterine adenogenesis factors PRL-R, GH, IGF1 AND IGF2. Crit Rev Eukariotic Gene Expr. 2023;33:39-46.\n-\nRolih V, Barutello G, Iussich S, De Maria R, Quaglino E, Buracco P, Cavallo F, Riccardo F. CSPG4: A prototype oncoantigen for translational immunotherapy studies. J Transl Med. 2017;15:151.\n-\nAmpofo E, Schmitt BM, Menger MD, Laschke MW. The regulatory mechanisms of NG2/CSPG4 expression. Cell Mol Biol Lett. 2017;22:4.\n-\nNasciutti LE, Ferrari R, Berardo PT, Souza MLS, Takiya CM, Borojevic R, Abrao MS, Silva LCF. Distribution of chondroitin sulfate in human endometrium. Micron. 2006;37:544-50.\n-\nWinship A, Van Sinderen M, Heffernan-Marks A, Dimitriadis E. Chondroitin sulfate proteoglycan protein is stimulated by interleukin 11 and promotes endometrial epithelial cancer cell proliferation and migration. Int J Oncol. 2017;50:798-804.\n-\nLin X. Functions of heparan sulfate proteoglycans in cell signaling during development. Development. 2004;131:6009-21.\n-\nParish CR, Freeman C, Hulett MD. Heparanase: A key enzyme involved in cell invasion. Biochim Biophys Acta. 2001;1471:M99-108.\n-\nMikami S, Ohashi K, Katsube K, Nemoto T, Nakajima M, Okada Y. Coexpression of heparanase, basic fibroblast growth factor and vascular endothelial growth factor in human esophageal carcinomas. Pathol Int. 2004;54:556-63.\n-\nTimofeeva YS, Sokotov DK, Grigorieva E V, Volchek AV, Kazanskaya GM, Sukhovskik, AV, Tsidulko AY, Evseeva YM, Kuleshov VM, Marinkin I, Aidagulova SV. Analysis of heparan sulfate proteoglucans content in eutopic and heterotopic endometrium in ovarian endometriosis. Obstet Gynecol. 2021;3:110-6.\n-\nGiordano MV, Giordano LA, Gomes RC, Simoes RS, Nader HB, Giordano MG, Baracat EC, Soares Junior JM. The evaluation of endometrial sulfate glycosaminoglycans in women with polycystic ovary syndrome. Gynecol Endocrinol. 2015;31:278-81.\n-\nHoadley ME, Seif MW, Aplin JD. Menstrual-cycle-dependent expression of keratan sulphate in human endometrium. Biochem J. 1990;266:757-63.\n-\nGraham RA, Li TC, Cooke ID, Aplin JD. Keratan sulphate as a secretory product of human endometrium: Cyclic expression in normal women. Hum Reprod. 1994;9:926-30.\n-\nNecas J, Bartosikova L, Brauner P, Kolar J. Hyaluronic acid (hyaluronan): A review. Vet Med. 2008;53:397-411.\n-\nHasegawa A, Yoshino O, Osuga Y, Kodama A, Takamura M, Nishii O, Taketani Y. Hyaluronic acid reagent suppressed endometriotic lesion formation in a mouse model. Fertil Steril. 2010;93(8):2757-9.\n-\nDechaud H, Witz CA, Montoya-Rodriguez IA, Degraffenreid LA, Schenken RS. Mesothelial cell-associated hyaluronic acid promotes adhesion of endometrial cells to mesothelium. Fertil Steril. 2001;76:1012-8.\n-\nYu PH, Chou PY, Li WN, Tsai SJ, Wu MH. The pro-inflammatory and anti-inflammatory role of hyaluronic acid in endometriosis. Taiwan J Obstet Gynecol. 2021;60:711-7.","source_license":"public-domain-us","license_restricted":false}