{"paper_id":"97066b68-22be-4865-ac27-f32e29b996ab","body_text":"Abstract\nThis study aimed to systematically review existing randomized clinical trials on the effect of dietary interventions on endometriosis. A search was performed on the Cochrane Central Register of Controlled Trials (CENTRAL), Cumulative Index to Nursing and Allied Health Literature (CINAHL), Clinical Trials, EMBASE, PubMed, Lilacs, and Cielo databases. The search terms were used: “endometriosis”, “endometrioma”, “diet”, “supplements” and “nutrition”. Electronic literature searches through databases yielded 866 publications. Two authors performed The study selection independently (and blinded), and disagreements were discussed. Eleven RCTs were included in the systematic review, with 716 women randomized. Most studies reported a positive effect on endometriosis pain scores; however, they were characterized by moderate or high-risk bias. Of these, six RCTs, including 457 women with endometriosis, were included in the meta-analysis. Compared with Placebo, antioxidant use was associated with a reduction in dysmenorrhea (mean difference − 1.95 [CI 95%, -3.78 to -0.13]. Supplementation was not significant for reducing chronic pelvic pain (mean difference − 2.22 [95% CI, -4.99 to 0.55] and dyspareunia (MD − 2.56 [95% CI, − 5. 22 to 0.10]. Both analyses showed a high degree of heterogeneity. Moreover, studies with low risk of bias did not show significant results compared to those on Placebo. The effects of nutrient compounds seem to have the potential to reduce pain in women with endometriosis, mainly to reduce dysmenorrhea. However, the available studies present high heterogeneity and moderate/high risk of bias. More randomized clinical trials are needed to accurately determine dietary interventions’ short- and long-term efficacy and safety in managing endometriosis pain.\nSimilar content being viewed by others\nData Availability\nData regarding any of the subjects in the study has not been previously published. Data will be made available to the journal editors for review or query upon request.\nReferences\nNnoaham KE, Hummelshoj L, Webster P, d’Hooghe T, de Cicco Nardone F, de Cicco Nardone C, et al. Impact of endometriosis on quality of life and work productivity: a multicenter study across ten countries. Fertil Steril. 2011;96:366–e3738. https://doi.org/10.1016/j.fertnstert.2011.05.090.\nSchneider MP, Vitonis AF, Fadayomi AB, Charlton BM, Missmer SA, DiVasta AD, et al. Quality of life in adolescent and young adult women with Dyspareunia and Endometriosis. J Adolesc Health. 2020;67:557–61. https://doi.org/10.1016/j.jadohealth.2020.02.024.\nWarzecha D, Szymusik I, Wielgos M, Pietrzak B. 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Food Reviews Int. 2004;20:77–90. https://doi.org/10.1081/FRI-120028831.\nFunding\nThis study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior– Brasil (CAPES)– Finance Code 001.\nAuthor information\nAuthors and Affiliations\nCorresponding author\nEthics declarations\nConflict of Interest\nThere is no type of conflict of interest with the participants or any other collaborator, direct or indirect, for the development of this study.\nAdditional information\nPublisher’s Note\nSpringer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.\nElectronic Supplementary Material\nBelow is the link to the electronic supplementary material.\nRights and permissions\nSpringer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.\nAbout this article\nCite this article\nMeneghetti, J.K., Pedrotti, M.T., Coimbra, I.M. et al. Effect of Dietary Interventions on Endometriosis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Reprod. Sci. 31, 3613–3623 (2024). https://doi.org/10.1007/s43032-024-01701-w\nReceived:\nAccepted:\nPublished:\nVersion of record:\nIssue date:\nDOI: https://doi.org/10.1007/s43032-024-01701-w","source_license":"CC0","license_restricted":false}