{"paper_id":"96cdcc4c-9ecd-426f-82c8-b6847af1a1ea","body_text":"Benign multicystic peritoneal mesothelioma (BMPM; peritoneal inclusion cyst, multilocular inclusion cyst, and benign multicystic mesothelioma) is a very rare multilocular cystic tumor arises from the peritoneal mesothelium [ 1 ,  2 ]. The etiology and pathogenesis are controversial regarding its neoplastic and reactive nature. The majority of these patients present with chronic or intermittent lower abdominal or pelvic pain. However, cases with retroperitoneal mass [ 3 ] or acute abdomen [ 4 ] have also been described. The diagnosis of BMPM is confirmed by electron microscopy and immunohistochemistry. Although BMPM is associated with a favorable short-term prognosis, there is increased recurrence during long-term followup [ 2 ].\nWe herein describe the late recurrence of BMPM complicated with incisional hernia fifteen years later following her first abdominal operation due to BMPM.\n\nA 57-year-old woman presented to our unit with an incisional hernia due to enlarged abdominal mass surrounded to the umbilicus fifteen years later following her first abdominal operation. She had a past medical history of BMPM originated from mesentery of appendix with extension to the ascending colon and she underwent right hemicolectomy. Since then, she was followed up four times a year in first two years then a year basis after 2 years of her operation. She did not go annual followup after 10 years. She reported abdominal discomfort and distension fifteen years later following her first operation. She attributed this to her incisional hernia at the site of midline incision. These had progressively worsened in size as had her symptoms. Her physical examination revealed painful palpable abdominal mass about 4 cm in size around the umbilicus and incisional hernia that lays 10 mm above and below her umbilicus and 30 mm diameter. Computed tomography (CT) examination demonstrated an intraperitoneal hypodense cystic mass surrounded to umbilicus and extended between the great curvature of the stomach, spleen, and tail of pancreas and extending caudally to the upper margin of the pelvis and pressure over the adjacent organs resulted with hernia from midline incision scar ( Figure 1 ). She underwent operation and multicystic mass was found to herniated and surrounded to umbilicus. A complete resection of the mass and the umbilicus and hernia repairment were performed. She had an uneventful postoperative recovery.\nMacroscopic examination of large cystic mass containing multiple smaller cystic spaces was shown in  Figure 2 . Microscopic examination of the cysts revealed that the walls of the cysts were lined by single flat cells alternating with cuboidal cells with hobnail features ( Figure 3 ). The nature of the lining cells was confirmed by immunohistochemical staining for cytokeratin 5/6 and calretinin ( Figure 4 ) as a BMPM.\n\nMulticystic mesothelioma of the peritoneum was first described by Plaut in 1928, but the mesothelial nature was confirmed with electron microscopy by Mennemeyer and Smith in 1979 [ 5 ].\nThe disease is an exceedingly rare medical entity, which renders its origin, pathogenesis, diagnosis, and therapy challenging [ 2 ,  4 ]. BMPM occurs predominantly in women child-bearing age and is associated with a history of previous abdominal surgery, endometriosis, leiomyomas, or pelvic inflammatory disease (PID) [ 2 ]. Only few reports exist of BMPM in elderly [ 4 ,  6 ,  7 ].\nThe pathogenesis of BMPM is unclear and there is some controvercy regarding its neoplastic or reactive nature [ 1 ,  2 ,  8 ]. Malignant transformation of BMPM as an unusual occurrence indicating a neoplastic nature underscoring the necessity of long-term followup has also been reported previously [ 8 ]. Evidence that BMPM represents a reactive process includes that it occurs in females with a history of endometriosis, prior abdominal surgery, or pelvic inflammatory disease [ 2 ,  9 ].\nMost patients are diagnosed incidentally during physical examination or surgery for other reasons. The clinical findings of benign multicystic mesotheliomas are nonspecific and include nausea, vomiting, and abdominal pain. Safioleas et al. [ 4 ] also have been reported its presentation as an incisional incarcerated hernia. Our case was attended to our hospital with an incisional hernia, abdominal discomfort, and a mass surrounded to the umbilicus. This makes our case unique in terms of presentation that recurrence can be seen with incisional hernia due to enlarged volume of the tumor ended up with the expression over the intraabdominal viscera and herniation from the abdominal wall. Laboratory findings are nonspecific for diagnosis of BMPM. CT provides more information about the location and the extent of the mass demonstrates well-defined, low-attenuation mass with non-calcified septa [ 10 ]. An intraperitoneal hypodense cystic mass in surrounding umbilicus with an intraabdominal extension and pressure over the adjacent organs, resulted with incisional hernia, was demonstrated with CT in our case.\nHistologically, BMPM is a localized tumor arising from mesothelial cells. The tumor is composed of a multiple mesothelial-lined cystic structure. Surgery is the only effective treatment. Aggressive surgical approaches including cytoreductive surgery with peritonectomy are recommended [ 4 ,  11 ]. Complete cytoreductive surgery was achieved in our patient.\nPrognosis of BMPM was reported differently. Weiss and Tavassoli reported that the prognosis was excellent and only death was occurred in a patient who refused the surgery [ 1 ]. Beside this, it has been reported that a woman at aged 36 with BMPM had developed a diffuse malignant mesothelioma after six surgical procedures [ 8 ]. Tumor recurrence was reported in half of the patients even complete cytoreduction was achieved [ 1 ,  12 ]. Therefore, routine followup with imaging techniques is required in patients after operation [ 13 ]. Our patient was ended up with a recurrence of BMPM 15 years later following her first operation suggesting long term followup is necessary in patients with BMPM.\nIn conclusion, recognition of BMPM is difficult and it can be recur as an incisional hernia. Recurrence of disease and uncertainty of biological behaviors indicate the necessity of proper long-term followup of patients with BMPM. In addition to this, complete cytoreductive surgery seems to be the proper management of this disease.","source_license":"CC-BY-4.0","license_restricted":false}