{"paper_id":"9580bdc9-4ad1-4e4f-ba2e-1d6fe7cc5748","body_text":"Please use this identifier to cite or link to this item:\nhttps://repositorio.ufba.br/handle/ri/5949\n| metadata.dc.type: | Artigo de Periódico |\n| Title: | Effect of oral contraceptives on vascular endothelial growth factor, Cox-2 and aromatase expression in the endometrium of uteri affected by myomas and associated pathologies |\n| Other Titles: | Contraception |\n| Authors: | Maia Junior, Hugo Casoy, Julio Pimentel, Kleber Santos Correia, Tania Athayde, Célia Maria Soares Cruz, Thomaz Rodrigues Porto da Coutinho, Elsimar Metzker |\n| metadata.dc.creator: | Maia Junior, Hugo Casoy, Julio Pimentel, Kleber Santos Correia, Tania Athayde, Célia Maria Soares Cruz, Thomaz Rodrigues Porto da Coutinho, Elsimar Metzker |\n| Abstract: | Background: The study was conducted to evaluate vascular endothelial growth factor (VEGF), Cox-2 and aromatase expression in the endometrium of uteri with myomas and other associated pathologies. Study Design: Hysteroscopy was performed in 118 women of reproductive age with myomas and menorrhagia, 40 of whom were using a pill containing 75 mcg gestodene+30 mcg ethinylestradiol. Aromatase p450, VEGF and Cox-2 expression was detected using immunohistochemistry. Fisher's Exact Test and the Mann–Whitney test were used in the statistical analysis, with significance established at pb.05. Results: In patients with myomas and menorrhagia, associated pathologies such as adenomyosis, endometrial polyps and endometriosis were found in 32%, 12% and 17% of cases, respectively. Aromatase, Cox-2 and VEGF expression was greater during the proliferative phase compared to the luteal phase of the cycle or following oral contraceptive use. Conclusion: Endogenous progesterone or combined oral contraceptives are potent inhibitors of VEGF, aromatase and Cox-2 expression in the endometrium of patients with myomas and menorrhagia. © 2008 Elsevier Inc. All rights reserved. |\n| Keywords: | Gestodene VEGF Aromatase Cox-2 Myoma Menorrhagia |\n| URI: | http://www.repositorio.ufba.br/ri/handle/ri/5949 |\n| Issue Date: | 2008 |\n| Appears in Collections: | Artigo Publicado em Periódico (Faculdade de Medicina) |\nFiles in This Item:\n| File | Description | Size | Format | |\n|---|---|---|---|---|\n| __ac.els-cdn.com_S001078...0301810acfa88fb02630e508e51d6.pdf | 283,44 kB | Adobe PDF | View/Open |\nItems in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.","source_license":"CC0","license_restricted":false}