{"paper_id":"919afefa-c86f-46c5-ba85-27746ddf2174","body_text":"Endometriosis-associated infertility is regulated via extracellular vesicles, with a direct effect on sperm activity, according to data published in the Journal of Cellular Physiology.\nEndometriosis is an inflammatory condition whereby the endometrium proliferates outside of the uterus, leading to pain and infertility. The pathogenesis of endometriosis-associated infertility is multifactorial, including changes in the reproductive tract microenvironment that promote the inflammation and adhesions, which can lead to ovulatory disorders and impair endometrial receptivity. Some studies have also suggested that extracellular vesicles affect disease pathophysiology via regulation of the biological functions of inflammatory cells, thereby modulating inflammation, angiogenesis and proliferation.\nThis is a preview of subscription content, access via your institution\nAccess options\nAccess Nature and 54 other Nature Portfolio journals\nGet Nature+, our best-value online-access subscription\n27,99 € / 30 days\ncancel any time\nSubscribe to this journal\nReceive 12 print issues and online access\n176,64 € per year\nonly 14,72 € per issue\nBuy this article\n- Purchase on SpringerLink\n- Instant access to the full article PDF.\n39,95 €\nPrices may be subject to local taxes which are calculated during checkout\nReferences\nOriginal article\nZhang, Z. et al. Vaginal extracellular vesicles impair fertility in endometriosis by favouring Th17/Treg imbalance and inhibiting sperm activity. J. Cell. Physiol. https://doi.org/10.1002/jcp.31188 (2024)\nAuthor information\nAuthors and Affiliations\nCorresponding author\nRights and permissions\nAbout this article\nCite this article\nFenner, A. Sperm activity affected by endometriosis. Nat Rev Urol 21, 62 (2024). https://doi.org/10.1038/s41585-024-00855-1\nPublished:\nVersion of record:\nIssue date:\nDOI: https://doi.org/10.1038/s41585-024-00855-1","source_license":"CC0","license_restricted":false}