{"paper_id":"9176da14-5273-4100-a329-d960b05bb703","body_text":"- IN BRIEF\nNonhormonal target for endometriosis\nCurrent treatment for endometriosis involves surgery or hormonal therapies, and more tolerable approaches are urgently needed. By further interrogating their previously reported linkage signal for endometriosis on chromosome 7p13-15, Tapmeier et al. identify variants of NPSR1, the gene encoding neuropeptide S receptor 1, to be associated with endometriosis in humans and rhesus macaques. Infiltrating monocytes highly positive for NPSR1 were identified in peritoneal fluid from patients with endometriosis. Inhibition of NPSR1 using SHA 68R blocked monocyte proinflammatory signalling and chemotaxis in vitro, and significantly reduced peritoneal inflammatory cell infiltrate and abdominal pain in mouse models of endometriosis.\nAccess options\nAccess Nature and 54 other Nature Portfolio journals\nGet Nature+, our best-value online-access subscription\n27,99 € / 30 days\ncancel any time\nSubscribe to this journal\nReceive 12 print issues and online access\n251,40 € per year\nonly 20,95 € per issue\nRent or buy this article\nPrices vary by article type\nfrom$1.95\nto$39.95\nPrices may be subject to local taxes which are calculated during checkout\nNature Reviews Drug Discovery 20, 740 (2021)\ndoi: https://doi.org/10.1038/d41573-021-00150-3\nReferences\nTapmeier, T. et al. Neuropeptide S receptor 1 is a nonhormonal treatment target in endometriosis. Sci. Transl Med. 13, eabd6469 (2021)","source_license":"CC0","license_restricted":false}