{"paper_id":"9020a75c-f809-4a99-86a4-2a3d6e1a5aeb","body_text":"Abstract\nPurpose\nThe study aimed to identify families with endometriosis and to document disease seventy within the families and the clinical characteristics of the affected women.\nResults\nTwo hundred and thirty women with surgically confirmed endometriosis in 100 families were identified. The families consisted of 19 mother-daughter pairs, 1 set of cousins and 56 sister pairs. There were 5 families with 3 affected sisters, 1 family with 5 affected sisters, and 18 families with ≥3 affected members in more than one generation. The mean age at the onset of symptoms and the mean age at surgical diagnosis was 22.1±8.8 SD (range 10–46) and 31.8±7.9 SD (range 15–56) years respectively. Seventy-nine women (34.3%) had revised AFS Stage I–II disease, and 151 (65.7%) had revised AFS Stage III–IV disease.\nConclusion\nThe study confirms a familial tendency for endometriosis and supports the hypothesis that endometriosis has a genetic basis.\nSimilar content being viewed by others\nReferences\nHaupt BJ: Utilization of short-stay hospitals: annual summary for the United States, 1980. Vital Health Stat 1982;13(64):1–60\nHouston DE, Noller KL, Meltson LJ III,et al: Incidence of pelvic endometriosis in Rochester Minnesota, 1970–1979. Am J Epidemiol 1987;125:959–962\nSimpson JL, Elias S, Malinak LR, Buttram VC: Heritable aspects of endometriosis. I: Genetic studies. Am J Obstet Gynecol 1980;137:327–331\nCoxhead D, Thomas EJ: Familial inheritance of endometriosis in a British population. A case control study. J Obstet Gynaecol 1993;13:42–44\nMoen MH, Magnus P: The familial risk of endometriosis, Acta Obstet Gynecol Scand 1993;72:560–564\nMoen MH: Endometriosis in monozygotic twins. Acta Obstet Gynecol Scand 1994;73:59–62\nAmerican Fertility Society: Revised American Fertility Society classification of endometriosis. Fertil Steril 1985;43:351–352\nSuarez BK: The affected sib pair IBD distribution for HLA-linked disease susceptibility genes. Tissue Antigens 1978;12:87–93\nAuthor information\nAuthors and Affiliations\nRights and permissions\nAbout this article\nCite this article\nKennedy, S., Mardon, H. & Barlow, D. Familial endometriosis. J Assist Reprod Genet 12, 32–34 (1995). https://doi.org/10.1007/BF02214126\nReceived:\nAccepted:\nIssue date:\nDOI: https://doi.org/10.1007/BF02214126","source_license":"CC0","license_restricted":false}