{"paper_id":"8fb86c95-1831-4767-8c7b-e223556669d7","body_text":"The Role of Vitamin D and Physical Activity in Endometriosis: Implications for Pain Relief, Physical Function and Reproductive Health- A Literature-Based Review\nDOI:\nhttps://doi.org/10.12775/QS.2026.54.70766Keywords\nendometriosis, Physical activity, pelvic pain, reproductive health, lifestyle, vitamin DAbstract\nPurpose of research. The aim of this study was to evaluate the roles of vitamin D and physical activity in the management of endometriosis, with particular emphasis on their effects on pain reduction, physical function, and reproductive health in affected women.\nResearch materials and methods. A literature-based review was conducted using major scientific databases, including PubMed, Scopus, and Web of Science. The analysis included original studies, randomized controlled trials, systematic reviews, and meta-analyses focusing on vitamin D status, supplementation, and physical activity interventions in women with endometriosis.\nBasic results. Vitamin D exhibits immunomodulatory, anti-inflammatory, antiproliferative, and anti-angiogenic properties mediated through the vitamin D receptor (VDR), which is widely expressed in reproductive tissues. Lower serum levels of 25-hydroxyvitamin D may be associated with increased risk and severity of endometriosis; however, clinical evidence regarding pain reduction remains inconsistent.\nPhysical activity, including aerobic exercise and mind–body interventions such as yoga, has been shown to reduce pain, improve quality of life, and positively influence psychological well-being through anti-inflammatory and neuroendocrine mechanisms.\nEmerging evidence suggests that optimizing vitamin D levels, combined with regular physical activity, may produce synergistic effects, particularly in improving physical performance, reducing inflammation, and supporting bone health.\nConclusions. Vitamin D and physical activity may serve as safe and effective complementary strategies in the management of endometriosis. Their integration into a personalized, multidisciplinary approach may improve patient outcomes; however, further high-quality studies are required to establish standardized clinical guidelines.\nReferences\n1. Tomasz Zaremba: tzaremba97@gmail.com, Surgical oncology resident in Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie, W. K. Roentgena 5 Street, 02-781 Warsaw, Poland\n2. Jacek Zaremba: jaraz@wp.pl, Thoracic surgery specialist in Instytut Gruźlicy i Chorób Płuc, Płocka 26 Street, 01-138 Warsaw, Poland\n3. Agata Smolarczyk: agata.smolarczyk@onet.pl, Doctor of dental medicine in Denticus, Starowiejska 42 Street, 26-900 Kozienice, Poland\n4. Agata Świątek: aswiatek@copernicus.gda.pl, Intern doctor in Szpital Św. Wojciecha COPERNICUS Podmiot Leczniczy Sp. z o.o., Jana Pawła II 50 Street, 80-462 Gdansk, Poland\n5. Oleksandr Kuzmenko: kuzmenko19767@gmail.com, Anesthesiology specialist in Baryshivka Central District Hospital, Vulytsya Kyyivsʹkyy Shlyakh, Baryshivka, Kyiv Oblast, 07-501, Ukraine\nDownloads\nPublished\nHow to Cite\nIssue\nSection\nLicense\nCopyright (c) 2026 Aleksandra Głowacka, Aleksandra Kurek, Dominika Domińczak, Sofiia Ivanchuk, Patryk Górecki, Anhelina Kaminskaya, Tetiana Savchak, Hubert Feretycki, Aladdin Salama, Shafea Abdulla\nThis work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.\nStats\nNumber of views and downloads: 99\nNumber of citations: 0","source_license":"CC0","license_restricted":false}