{"paper_id":"8d611ddd-898a-499a-a306-b9f1282040f2","body_text":"Gut Microbiota Profile in Endometriosis Patients at Dr. M. Djamil Padang, West Sumatra, Indonesia\nDOI:\nhttps://doi.org/10.25077/aoj.9.1.134-145.2025Keywords:\nendometriosis, dysbiosis, bacteroides, firmicutes, gut microbiotaAbstract\nObjective: Endometriosis (EMS) is a chronic gynecological condition affecting up to 10% of women worldwide. The pathogenesis associated with hormonal imbalance, immune dysregulation, and changes in the gut microbiota. Gut microbiota dysbiosis may drive chronic inflammation that contributes to the progression of EMS. This study hypothesizes that certain gut microbiota profiles are associated with these factors in EMS patients, potentially developing non-invasive diagnostics and more targeted therapies.\nMethods: This is an observational analytical study with a case-control design conducted at Dr. M. Djamil Padang General Hospital in May 2024 with a sample size of 44 people. Case samples were women aged 18–40 years who were diagnosed with endometriosis based on the inclusion criteria, while the control group were women of reproductive age without a diagnosis of endometriosis. Data testing used the Next Generation Sequencing method, microbiome analysis test, and SPSS test.\nResults: The majority of EMS patients were aged 30-37 years, married, and had Nullipara obstetric status. In addition, the gut microbiota was dominated by the phyla Bacteroidetes and Firmicutes.\nConclusion: There is a relationship between gut microbiota dysbiosis and the incidence of endometriosis, namely an increase in Bacteroidetes and a decrease in Firmicutes\nKeywords: endometriosis, dysbiosis, bacteroides, firmicutes, gut microbiota\nReferences\nLe N, Cregger M, Brown V, de Mola JL, Bremer P, Nguyen L, et al. Association of microbial dynamics with urinary estrogens and estrogen metabolites in patients with endometriosis. PLoS One. 2021;16(12):1–19.\nImperiale L, Nisolle M, Noël JC, Fastrez M. Three Types of Endometriosis: Pathogenesis, Diagnosis and Treatment. State of the Art. J Clin Med. 2023;12(3).\nFatimah D, Hutagaol IEB, Romus I. Profil Kasus Endometriosis di RSUD Arifin Achmad Provinsi Riau Periode 1 Januari 2012 – 31 Desember 2016. Jurnal Ilmu Kedokteran (Journal of Medical Science). 2019;12(1):39.\nGuo C, Zhang C. Role of the gut microbiota in the pathogenesis of endometriosis: a review. Front Microbiol. 2024 Mar 5;15.\nZizolfi B, Foreste V, Gallo A, Martone S, Giampaolino P, Di Spiezio Sardo A. Endometriosis and dysbiosis: State of art. Front Endocrinol (Lausanne). 2023;14:1–6.\nJiang I, Yong PJ, Allaire C, Bedaiwy MA. Intricate connections between the microbiota and endometriosis. Int J Mol Sci. 2021;22(11):1–23.\nHajjo R, Sabbah DA, Al Bawab AQ. Unlocking the Potential of the Human Microbiome for Identifying Disease Diagnostic Biomarkers. Diagnostics. 2022;12(7):1–27.\nHidayat A, Hendry D. Characteristics of Endometriosis and Adenomiosis Patients In Dr. M. Djamil Hospital Padang in The Period of January 2017-Octobe 2018. Ruang Redaksi Andalas Obstetrics and Gynecology Journal [Internet]. 3(1):25127. Available from: https://jurnalobgin.fk.unand.ac.id/index.php/JOE\nMagne F, Gotteland M, Gauthier L, Zazueta A, Pesoa S, Navarrete P, et al. The firmicutes/bacteroidetes ratio: A relevant marker of gut dysbiosis in obese patients? Vol. 12, Nutrients. MDPI AG; 2020.\nQin R, Tian G, Liu J, Cao L. The gut microbiota and endometriosis: From pathogenesis to diagnosis and treatment. Front Cell Infect Microbiol. 2022;12(November):1–8.\nPortincasa P, Bonfrate L, Vacca M, De Angelis M, Farella I, Lanza E, et al. Gut Microbiota and Short Chain Fatty Acids: Implications in Glucose Homeostasis. Vol. 23, International Journal of Molecular Sciences. MDPI; 2022.\nBaker JM, Al-Nakkash L, Herbst-Kralovetz MM. Estrogen–gut microbiome axis: Physiological and clinical implications. Maturitas [Internet]. 2017;103(June):45–53. Available from: https://dx.doi.org/10.1016/j.maturitas.2017.06.025\nUzuner C, Mak J, El-Assaad F, Condous G. The bidirectional relationship between endometriosis and microbiome. Front Endocrinol (Lausanne). 2023;14(March):1–9.\nDownloads\nPublished\nHow to Cite\nIssue\nSection\nLicense\nCopyright (c) 2025 Haviz Yuad, Bobby Indra Utama, Nur Indrawaty Lipoeto, Andani Eka Putra\nThis work is licensed under a Creative Commons Attribution 4.0 International License.","source_license":"CC0","license_restricted":false}