{"paper_id":"8a06ccf1-32e8-415b-8196-4117d2d04ca9","body_text":"THE LATEST VIEWS ON THE TREATMENT OF ENDOMETRIOS\nDOI:\nhttps://doi.org/10.36074/grail-of-science.10.11.2023.65Keywords:\nendometriosis, hormonal drugs, nanoparticles, metformin, iron oxideSummary\nRegardless of the localization and severity of clinical manifestations, E affects the functions of not only damaged and adjacent, but also distant organs: liver, pancreas and thyroid glands, adrenal glands, cardiovascular and nervous systems. The true mechanisms that regulate the processes of implantation and development of endometrioid heterotopias are complex and insufficiently studied, which does not allow us to assume the possibility of a complete cure, and in a number of patients, even achieving long-term remission or stopping the progression of the disease. Certain successes have been achieved in the treatment of E in recent years, especially in connection with the use of modern hormonal drugs. The treatment of clinically inactive E, which is more often observed in lesions of the peritoneum of the small pelvis, ectocervical and extracervical localizations, should be approached carefully and differentiated, since sometimes hormone therapy can contribute to the activation of the process.\nDownloads\nDownloads\nLicense\nCopyright (c) 2023 Halyna Semenyna, Marta Doroshenko-Kravchyk, Tetiana Fartushok, Liliia Varvarych\nReferences\nLagana A.S., Vitale S.G., Salmeri H. (2017) A Novel, Evidence-based, Unifying Theory for the Pathogenesis of Endometriosis. Med.Hypotheses, 103,10-20. Doi:10.1016/j/mehy.2017.03.032. DOI: https://doi.org/10.1016/j.mehy.2017.03.032\nLagana A.S., Vitale S.G., Gromese R., Palmara V. (2017) Clinical dynamics of Dienogest for the treatment of Endometriosis: From Bench to Bedside. Expert Opin. Drug Metab. Toxicol,13,595-596. DOI: https://doi.org/10.1080/17425255.2017.1297421\nPatel B.G., Rudnicki M., Yu J., Shu Y., Taylor R.N. (2017) Progesterone resistance in endometriosis: Origins, consequences and interventions. Acta Obstet. Gynecol. Scand.,6,623-632. DOI: https://doi.org/10.1111/aogs.13156\nAyako Muraoka, Miho Suzuki, Tomonari Hamaguchi, Shinya Watanabe, Kenta Iijima, Yoshiteru Murofushi, Keiko Shinjo, Satoko Osuka, Yumi Hariyama, Mikako Ito, Kinji Ohno, Tohru Kiyono, Satoru Kyo, Akira Iwase, Fumitaka Kikkawa, Hiroaki Kajiyama, Yutaka Kondo. (2023) Fusobacterium infection facilitates the development of endometriosis through the phenotypic transition of endometrial fibroblasts. Science Translational Medicine, 15, 700. DOI:10.1126/scitranslmed.add1531 DOI: https://doi.org/10.1126/scitranslmed.add1531\nTargeted Nanoparticles with High Heating Efficiency for the Treatment of Endometriosis with Systemically Delivered Magnetic Hyperthermia https://onlinelibrary.wiley.com/doi/epdf/10.1002/smll.202107808\nZaneta Kimber-Trojnar et al. (2022) Metformin as a potencial treatment option for Endometriosis. Cancers,14(3),577. Doi:103390/cancers14030577. DOI: https://doi.org/10.3390/cancers14030577\nJamali N., Zal F., Mostafavi-Pour Z., Samare-Najaf M. et al. (2021). Ameliorative effect of quercetin and metformin and their combination against experimental endometriosis in rats. Reprod. Sci,28,683-692. Doi:10.1007/s43.032-020-00377-2. DOI: https://doi.org/10.1007/s43032-020-00377-2\nSoares S.R., Martinez-Varea A., Hidalgo-Mora J.J., Pellicer A. (2012) Pharmacologic therapies in endometriosis: A systematic review. Fertil.Steril, 98,529-555. Doi:10.1016/j.fertster.2012.07.11.20. DOI: https://doi.org/10.1016/j.fertnstert.2012.07.1120\nMachado D.E., Saggioro E.M. et al. (2023) Clotrimazole is effective, safe and tolerable for the treatment of endometriosis and functions by downregulating inducible nitric oxide synthase and modulating oxidative stress biomarkers. Molecular and Cellular Endocrinolog, 564,111883. Doi:10.1016/j.mce.2023.111883. DOI: https://doi.org/10.1016/j.mce.2023.111883\nResearchers optimistic about potential new treatment for endometriosis https://www.theguardian.com/profile/hannah-devlin\nZhang H., Liu F., Huang Y., Liu W. (2023) The role of metformin in the management of endometriosis: A systematic review and meta-analysis. T.J.Pharm.Res, 22,5. Doi:10.4314/tjpr.v22i5.26. DOI: https://doi.org/10.4314/tjpr.v22i5.26\nBina F., Solcymani S., Tabarrai M., Abdollahi M., Rahinni R. (2019) Plant-derived medicines for treatment of endometriosis. Parmacol.Res, 139, 76-90. Doi:10.1016/j.phrs.2018.11.008. DOI: https://doi.org/10.1016/j.phrs.2018.11.008\nSiedlak A., Kuc M., Cyboran K., Machaj D., Płaczek A. (2022) Complementary treatment of endometriosis: diet, physiotherapy and psychological treatment. Journal of Education, Health and Spor, 12(7),989-993. DOI: https://doi.org/10.12775/JEHS.2022.12.07.100\nMarkin L, Fartushok T, Mrochko Y, Pidhirnyj Y. (2022). MANAGEMENT OF PREGNANT WOMEN WITH COVID-19 − OWN EXPERIENCE. Georgian Medical News, 323,38-47. PMID: 35271469\nFartushok T.V., Semenyna H.B.,Starykovych A.V.(2021) Influence of leptin on the development and progression of obesity and concomitant diseases. MODERN ASPECTS OF MODERNIZATION OF SCIENCE IN UKRAINE: STATUS, PROBLEMS, DEVELOPMENT TRENDS. 102-105.","source_license":"CC0","license_restricted":false}