{"paper_id":"894ba0e7-4e00-489b-84e6-9a192f933198","body_text":"Abstract\nPotential broad clinical uses of GnRH analogs in gynecological applications raise several issues regarding the safety of these peptide hormones in women. These analogs have widespread applicability in a variety of disorders such as leiomyomata uteri, polycystic ovarian disease, prior to laser ablation for dysfunctional uterine bleeding, and infertility [1–10]. Included in these indications is the treatment of endometriosis [2], a ubiquitous disease in reproductive-aged women. GnRH analogs decrease ovarian steroidogenesis through selective hypophysectomy with reduced gonadotropin release; and thus diminish estradiol levels. The GnRH induced hypoestrogenic state raises concerns about effects on bone mass, especially in women with endometriosis, a disease which is associated with decreased bone [11], as well as in the treatment of fibroids in perimenopausal women, who may already have altered bone turnover. This potential side effect of GnRH analog therapy is important, since estrogen appears to be a critical factor in the regulation of bone turnover. Consequently, bone density response during GnRH analog use must be carefully assessed in all women, and particularly in the perimenopausal population.\nPreview\nUnable to display preview. Download preview PDF.\nSimilar content being viewed by others\nReferences\nAndreyko, JL, Marshall, LA, Dumesic, DA, and Jaffe, RB (1987). Therapeutic uses of gonadotropin-releasing hormone analogs. Obstet Gynecol Surv, 421, 1\nHenzl, MR, Corson, SL, Moghissi, K, Buttram, VC, Berquist, C, and Jacobson, J (1988). Administration of nasal nafarelin as compared with oral danazol for endometriosis: a multicenter double-blind comparative clinical trial. N Engl J Med, 318, 485\nBarbieri, RL (1988). New therapy for endometriosis. 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Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0725-6_18\nDownload citation\nDOI: https://doi.org/10.1007/978-94-009-0725-6_18\nPublisher Name: Springer, Dordrecht\nPrint ISBN: 978-94-010-6811-6\nOnline ISBN: 978-94-009-0725-6\neBook Packages: Springer Book Archive\nKeywords\nThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.","source_license":"CC0","license_restricted":false}