{"paper_id":"88e756d6-d527-44f6-a032-49fbf57f8ec0","body_text":"Abstract\nBackground\nExtrauterine endometrial stromal sarcoma (ESS) is a rare neoplasm. Little is known about its pathophysiology or best treatment approach.\nCase\nWe are describing a case of extrauterine ESS in a 70-year-old woman on hormone replacement therapy and with a history of endometriosis. We also present a brief review of the literature on ESS and its relationship to endometriosis and hormonal therapy.\nConclusions\nComplete resection should remain the treatment of choice for ESS. Unresectable or metastatic low-grade ESS may respond well to progestin therapy, but outcomes of high-grade ESS tend to be poor.\nReferences\nAcharya S, Hensley ML, Montag AC, Fleming GF. Rare uterine cancers. Lancet Oncol. 2005;6(12):961–71. doi:10.1016/S1470-2045(05)70463-0.\nChang KL, Crabtree GS, Lim-Tan SK, Kempson RL, Hendrickson MR. Primary extrauterine endometrial stromal neoplasms: a clinicopathologic study of 20 cases and a review of the literature. Int J Gynecol Pathol. 1993;12(4):282–96. doi:10.1097/00004347-199310000-00002. 282.\nKovac D, Gasparovic I, Jasic M, Fuckar D, Dobi-Babic R, Haller H. Endometrial stromal sarcoma arising in extrauterine endometriosis: a case report. Eur J Gynaecol Oncol. 2005;26(1):113–6.\nLevine PH, Abou-Nassar S, Mittal K. Extrauterine low-grade endometrial stromal sarcoma with florid endometrioid glandular differentiation. Int J Gynecol Pathol. 2001;20(4):395–8. doi:10.1097/00004347-200110000-00014.\nBosincu L, Massarelli G, Gossu Rocca P, Isaac MA, Nogales FF. Rectal endometrial sarcoma arising in endometriosis: report of a case. Dis Colon Rectum. 2001;44(6):890–2. doi:10.1007/BF02234715.\nStenchever MA, Herbst AL, Droegemueller W. Comprehensive gynecology. 4th ed. St. Louis: Mosby; 2001.\nPink D, Lindner T, Mrozek A, Kretzchmar A. Harm or benefit of hormonal treatment in metastatic low-grade endometrial stromal sarcoma: single center experience with 10 cases and review of the literature. Gynecol Oncol. 2006;101(3):464–9. doi:10.1016/j.ygyno.2005.11.010.\nIhnen M, Mahner S, Janicke F, Schwartz J. Current treatment options in uterine endometrial sarcoma: report of a case and review of literature. Int J Gynecol Cancer. 2007;17:957–63.\nChristie DB, Day JD, Moore AB, Chapman JR, Nakayama DK, Conforti AM. Endometrial stromal sarcoma development after hysterectomy and tamoxifen therapy. Am Surg. 2008;74(8):726–8.\nConflict of interest statement\nThe authors declare that they have no conflicts of interest.\nAuthor information\nAuthors and Affiliations\nCorresponding author\nRights and permissions\nAbout this article\nCite this article\nZemlyak, A., Hwang, S., Chalas, E. et al. Primary Extrauterine Endometrial Stromal Cell Sarcoma: A Case and Review. J Gastrointest Canc 39, 104–106 (2008). https://doi.org/10.1007/s12029-009-9064-0\nReceived:\nAccepted:\nPublished:\nIssue date:\nDOI: https://doi.org/10.1007/s12029-009-9064-0","source_license":"public-domain-us","license_restricted":false}