{"paper_id":"87ee6402-0be4-4530-804a-df41a501c043","body_text":"Article Sidebar\nPublished:\nNov 27, 2025Keywords:\nArticle Details\nSubmission of a manuscript to this journal is a representation that the manuscript has not been published previously and is not under consideration for publication elsewhere.\nAll authors named in each manuscript would be required to sign a form (to be supplied by the Editor) so that they may retain their copyright in the article but to assign to us (the Publishers) and its licensees in perpetuity, in all forms, formats and media (whether known or created in the future) to (i) publish, reproduce, distribute, display and store the contribution, (ii) translate the contribution into other languages, create adaptations, reprints, include within collections and create summaries, extracts and/or abstracts of the contribution, (iii) create any other derivative works(s) based on the contribution, (iv) to exploit all subsidiary rights in the contribution, (v) the inclusion of electronic links from the contribution to third party material where-ever it may be located, and (vi) license any thrid party to do any or all of the above.\nYosef Salan, Department of Obstetrics and Gynecology of Ulin Hospital, Faculty of Medicine, Lambung Mangkurat University, Banjarmasin 70123, Indonesia.\nAditya Rahman, Department of Obstetrics and Gynecology of Ulin Hospital, Faculty of Medicine, Lambung Mangkurat University, Banjarmasin 70123, Indonesia.\nMuhammad Wicaksono, Department of Obstetrics and Gynecology of Ulin Hospital, Faculty of Medicine, Lambung Mangkurat University, Banjarmasin 70123, Indonesia.\nYakob Togar, Department of Obstetrics and Gynecology of Ulin Hospital, Faculty of Medicine, Lambung Mangkurat University, Banjarmasin 70123, Indonesia.\nSandra Mahendra, Department of Obstetrics and Gynecology of Ulin Hospital, Faculty of Medicine, Lambung Mangkurat University, Banjarmasin 70123, Indonesia.\nIwan Putra, Department of Obstetrics and Gynecology of Ulin Hospital, Faculty of Medicine, Lambung Mangkurat University, Banjarmasin 70123, Indonesia.\nHardyan Sauqi, Department of Obstetrics and Gynecology of Ulin Hospital, Faculty of Medicine, Lambung Mangkurat University, Banjarmasin 70123, Indonesia.\nEko Suhartono, Department of Biochemistry/Medical Chemistry, Faculty of Medicine, Lambung Mangkurat University, Banjarmasin 70123, Indonesia.\nMain Article Content\nMolecular mechanism of isoflavone aglycoside compounds in suppressing endometriosis progression\nYosef Salan\nAditya Rahman\nMuhammad Wicaksono\nYakob Togar\nSandra Mahendra\nIwan Putra\nHardyan Sauqi\nEko Suhartono\nAbstract\nPurpose: To assess the potential therapeutic efficacy of isoflavone aglycones in suppressing endometriosis progression through multi-pathway targeting.\nMethods: Using molecular docking simulations, the interactions between genistein, daidzein, and glycitein, with estrogen receptor α (ERα), estrogen receptor β (ERβ), Tumor Necrosis Factor-α receptor (TNF-α), Nuclear Factor-κappa Beta receptor (NF-κB), and prostaglandin EP3 receptor were analyzed and compared to dienogest, a standard treatment.\nResults: Results indicated that genistein and daidzein showed strong binding affinities to estrogen receptor β, with scores of -8.7 kcal/mol, surpassing dienogest (-8.5 kcal/mol). Glycitein exhibited the highest among other isoflavone aglycones binding affinity to the prostaglandin EP3 receptor (-9.2 kcal/mol), suggesting its potential in reducing inflammation and proliferation in endometriosis. Additionally, glycitein demonstrated the strongest interaction with NF-κB (-6.4 kcal/mol), a key regulator of inflammation and cell survival in endometriosis.\nConclusion: The findings suggest that isoflavone aglycones, particularly genistein, daidzein, and glycitein, could serve as effective therapeutic agents for endometriosis by targeting multiple pathways involved in the pathogenesis of endometriosis. Further clinical studies are needed to validate their efficacy and safety in treating endometriosis while preserving reproductive function.","source_license":"CC0","license_restricted":false}