{"paper_id":"8787a953-458c-4998-86a6-b5842fa17ca4","body_text":"Abstract\n30 formalin-fixed and paraffin embedded and 20 fresh frozen samples of endometriotic tissue were analysed immunohistochemically for the concentration of estrogen and progesterone receptors.\nIn the formalin-fixed and paraffin embedded group only 37% of the samples were estrogen receptor positive whereas 63% were receptor negative. In contrast, we found that 67% of the samples had a positive progesterone receptor status.\nIn the fresh frozen group 60% of endometriotic tissues were estrogen receptor positive and 75% of the tissues had a positive progesterone receptor status. We could not find any correlation between the site or severity of the endometriosis or the hormonal receptor status.\nWe were able to demonstrate that the immunohistochemical detection of hormonal receptors in endometriotic tissues is possible and that better results were obtained if fresh frozen rather than formalin-fixed and paraffin embedded tissues were analyzed.\nSimilar content being viewed by others\nReferences\nBergqvist A, Rannevik G, Thorell J (1981) Estrogen and progesterone cytosol receptor concentration in endometriotic tissue and intrauterine endometrium. Acta Obstet Gynecol Scand [Suppl] 101:53\nBur ME, Greene GL, Press MF (1987) Estrogen receptor localization in Formalin-fixed, paraffin embedded endometrium and endometriotic tissues. Int J Gynecol Pathol 6:140–151\nGeipel P (1927) Weiterer Beitrag zur Kenntnis des dezidualen Gewebes. Arch Gynecol 131:650–700\nHalban J (1925) Hysteroadenosis metastatica. Die lymphogene Genese der sog. Adenofibromatosis heterotopica. Arch Gynecol 124:457–482\nJänne O, Kauppila A, Kokko E, Lantto T, Rönnberg L, Vihko R (1981) Estrogen and progestin receptors in endometriosis lesions: Comparison with endometrial tissue. Am J Obstet Gynecol 141:562\nKauppila A, Rönnberg L, Vihko R (1986) Steroidrezeptoren in endometriotischem Gewebe. Endometriose 4:56–60\nKauppila A, Vierikko P, Isotalo H, Rönnberg L, Vihko R (1984) Cytosol estrogen and progestinreceptor concentrations and 17β-hydroxysteroid dehydrogenase activities in the endometrium and endometriotic tissue. Acta Obstet Scand [Suppl] 123:45–49\nKroemer P (1904) Die Lymphorgane der weiblichen Genitalien und ihre Verdnderungen bei malignen Erkrankungen des Uterus. Arch Gynecol 73:57–158\nLessey BA, Metzger DA, Haney AF, McCarty KS (1989) Immunhistochemical analysis of estrogen and progesteron receptors in endometriosis: comparison with normal endometrium during the menstrual cycle and the effect of medical therapy. Fertil Steril 51:409–415\nMeyer R (1903) Über eine adenomatöse Wucherung der Serosa in einer Bauchnarbe. Z Geburtshilfe Gyndkol 49: 32–41\nRemmele W, Stegner HE (1987) Vorschlag zur einheitlichen Definition eines immunreaktiven Scores (IRS) für den immunhistochemischen Östrogenrezeptor-Nachweis (ER-ICA) im Mammakarzinomgewebe. Pathologe 8:138–140\nRokitansky C (1861) Lehrbuch der pathologischen Anatomie. Bd. 3, 3rd edn. Wien, p 442\nSampson JA (1921) Perforating hemorrhagic (chocolate) cysts of the ovary. Their importance and especially their relation to the pelvic adenomas of the endometrial type. Arch Surg 3:245–323\nStaffeld K (1968) Drüseneinschlüsse in Beckenlymphknoten. Z Geburtshilfe Gynäkol 168:197–209\nTamaya T, Motoyama T, Ohono Y, Ide N, Tsurusaki T, Okada H (1979) Steroid receptor levels and histology of endometriosis and adenomyosis. Fertil Steril 31:396–400\nVierikko P, Kauppila A, Rönnberg L, Vihko R (1985) Steroidal regulation of endometriosis tissue: lack of induction of l7β-hydroxysteroid dehydrogenase activity by progesterone, medroxyprogesterone acetate or danazol. Fertil Steril 43:218–224\nWertheim E (1900) Zur Frage der Radikaloperation beim Uteruskrebs. Arch Gynecol 26:627–668\nAuthor information\nAuthors and Affiliations\nRights and permissions\nAbout this article\nCite this article\nRegidor, P.A., Regidor, M., Metz, K.A. et al. Immunohistochemical detection of estrogen and progesterone receptors in endometriotic tissue. Arch Gynecol Obstet 255, 181–187 (1994). https://doi.org/10.1007/BF02335083\nReceived:\nAccepted:\nIssue date:\nDOI: https://doi.org/10.1007/BF02335083","source_license":"CC0","license_restricted":false}