{"paper_id":"84fdaa01-4951-4fc4-97b2-b41d7a073a27","body_text":"INTRODUCTION \nReview question / Objective What are the \ndaily life restrictions of women with \nEndometriosis? What is the prevalence of \ndaily life restrictions? How do they correlate with \nEndometriosis symptoms/severity? what is the \nrelevance to intervention for improving daily life? \nBackground Endometriosis is a chronic condition \ncharacterized by the presence of endometrial-like \ntissue outside the uterus. This chronic condition \nand includes symptoms such as chronic pelvic \npain, fatigue, infertility, all of which may \nsignificantly impact women’s daily life in various \nfunctional domains and therefore reduce quality of \nlife and wellbeing. Despite the known physical \nsymptoms, their implications on women’s real life \nis less studied, however critical for intervention in \nterms of elevating function, quality of life and \nwellbeing. The ICF framework of the World Health \nOrganization emphasizes that health providers \nshould refer to the interaction between the \ndisease, impaired body functions and the person’s \nability to function and participate in daily life to \noptimize intervention and people’s wellbeing. \nRationale  While research and practice of \nEndometriosis mainly focus on the physical \nsymptoms and on clinical settings, there is a \nnotable gap in the literature regarding the \ncomprehensive impact of Endometriosis on \nwomen’s daily functioning in real life, outside the \nclinic – at home, at work, in social and intimate \nrelationships etc. This knowledge is critical for \nimproving intervention strategies, optimizing \nwomen’s engagement in therapy and improving \ntheir quality of life and wellbeing. \nThis review aims to close this gap and provide a \ncomprehensive perspective about Endometriosis \nimpacts on women’s daily functioning, in all \nrelevant domains (as work, social life), offering a \nholistic view of the condition’s impacts in real life \nsettings. The review seeks to understand the daily \nlife restrictions experienced by women with \nEndometriosis and their prevalence. It will also \nidentify the most impacted functional domains and \nINPLASY 1\nInternational Platform of Registered Systematic Review and Meta-analysis Protocols\nINPLASYDaily Life Restrictions of Women with \nEndometrioses: A Scoping Review Protocol\nKhatib, S; Hassan; H, Reiss, A; Engel-Yeger, B.\nKhatib et al. INPLASY protocol 202470101. doi:10.37766/inplasy2024.7.0101\nKhatib et al. INPLASY protocol 202470101. doi:10.37766/inplasy2024.7.0101 Downloaded from https://inplasy.com/inplasy-2024-7-0101/\nINPLASY202470101\ndoi: 10.37766/inplasy2024.7.0101 \nReceived: 25 July 2024\nPublished: 25 July 2024\nCorresponding author: \nSewar Khatib\nsewar94@outlook.com\nAuthor Affiliation:                   \nDepartment of Occupational \nTherapy, Faculty of Social Welfare \nand Health Sciences, University of \nHaifa, Israel.\nADMINISTRATIVE INFORMATION  \nSupport -  University of Haifa. \nReview Stage at time of this submission - The review has not yet \nstarted. \nConflicts of interest - None declared. \nINPLASY registration number: INPLASY202470101 \nAmendments - This protocol was registered with the International \nPlatform of Registered Systematic Review and Meta-Analysis Protocols \n(INPLASY) on 25 July 2024 and was last updated on 25 July 2024.\n\nexamine how these impacts correlate with the \nseverity and symptoms of Endometriosis.\nThis scoping review seeks to map out the existing \nresearch on these domains, identify gaps, and \nhighlight areas requiring further investigation. By \ndoing so, it aims to highlight the potential for \nimproving interventions that can be integrated into \ncurrent healthcare models as the ICF .\nThe insights gained will inform the development of \ntargeted interventions and health models designed \nto enhance daily functioning and quality of life of \nwomen living with Endometriosis. Through this \ncomprehensive approach, the review will \ncontribute to a more nuanced understanding of the \ndisease and support the creation of e ffective \nstrategies to alleviate its multifaceted burdens. \nMETHODS \nStrategy of data synthesis  The data synthesis for \nthis scoping review will involve both qualitative and \nquantitative methods to provide a comprehensive \nunderstanding of the impact of Endometriosis on \nwomen's daily functioning. The process will be \nmanaged using Covidence. The following steps \noutline the strategy:\n1.Summarize the characteristics of the included \nstudies, such as study design, population \ndemographics, types of Endometriosis, and \nspecific domains of daily functioning assessed. \nPresent key findings in tables and figures to \nprovide a clear overview of the study \ncharacteristics. 2.Thematic analysis we will identify, \nand code recurring themes related to the impact of \nEndometriosis on daily functioning, including work, \nsocial life, intimate relationships, and overall quality \nof life. and organize the coded data into major \nthemes and subthemes, providing a narrative \nsummary of the identified themes. Then we will \nconduct quantitative synthesis and extract \nquantitative data related to the prevalence and \nseverity of daily life restrictions caused by \nEndometriosis. \nWe also will examine the correlations between the \nseverity of Endometriosis symptoms and the \nimpact on various domains of daily functioning. \nThen we will compare the findings across different \ntypes of Endometriosis to identify any differential \nimpacts.\nWe will integrate the qualitative and quantitative \nfin d i n g s t o p r o v i d e a c o m p r e h e n s i v e \nunderstanding of the overall impact of \nEndometriosis on women's daily lives, and then \ndiscuss the implications of the findings for clinical \npractice, policy, and future research, highlighting \npotential interventions and health models designed \nto enhance the quality of life for women with \nEndometriosis.\nIdentify gaps in the existing literature and areas \nnecessitating further investigation and propose \nfuture research directions based on the \nsynthesized data, emphasizing the need for \nstudies that address the identi fied gaps and \nexplore novel intervention strategies.\nData management:\nData management will be conducted using \nCovidence, an online software platform designed \nto streamline the systematic review process. The \nsteps involved include: importing references \nretrieved from the initial search into Covidence and \nensure that duplicates are identified and removed \nautomatically by Covidence.\nThen, we will conduct screening (conduct title and \nabstract screening within Covidence) each \nreference will be independently reviewed by two \nreviewers. Conflicts will be flagged and resolved \nthrough discussion or by consulting a third \nreviewer if necessary.\nWe will conduct full-text review by uploading full-\ntext articles to Covidence for in-depth review, full-\ntext screening to confirm eligibility, with two \nreviewers independently assessing each study. \nDifferences will be resolved through discussion or \nby a third reviewer.\nWe will use Covidence's data extraction tool to \nsystematically extract relevant information from \neach included study and develop and use a \nstandardized data extraction form to ensure \nconsistency across reviewers, extracted data will \ninclude study characteristics, population details, \ntypes of Endometriosis, daily functioning impacts, \nand other relevant outcomes.\nWe will synthesize the extracted data using \nCovidence’s tools to identify themes and patterns. \nPresent the data in tabular and narrative formats \nfor comprehensive analysis and reporting.\nThe search strategy will be utilized across a \ncombination of databases, including both those \nwith and without a thesaurus. The databases and \nsearch terms are as follows:\nDatabases without a thesaurus: Web of Science, \nScopus, ProQuest Dissertation and Theses\nDatabases with a thesaurus: PubMed, CINAHL, \nPsycINFO.\nSearch Terms:\nWe will integrate search terms across two primary \nconcepts: \"Endometriosis\" and its synonyms (e.g., \nINPLASY 2Khatib et al. INPLASY protocol 202470101. doi:10.37766/inplasy2024.7.0101\nKhatib et al. INPLASY protocol 202470101. doi:10.37766/inplasy2024.7.0101 Downloaded from https://inplasy.com/inplasy-2024-7-0101/\n\nendometrima* ) and \"daily life\" and \"functioning\" \nalong with their synonyms (e.g., daily activities, \nfunctional status).\nEligibility criteria  Cis gender women in \nreproductive age (15-49), with a diagnosis of \nEndometriosis. \nWomen diagnosed with all types of Endometriosis: \nSuperficial Peritoneal Endometriosis (SPE). Ovarian \nEndometriomas, also termed \"chocolate cysts\". \nDeep Infiltrating Endometriosis (DIE). \nSource of evidence screening and selection  \nThe source selection for this scoping review will \nfollow a systematic process involving initial search \nand screening using predefined search terms in \nselected databases (Web of Science, Scopus, \nProQuest Dissertation and Theses, PubMed, \nCINAHL, and PsycINFO).\nScreen titles and abstracts of the retrieved articles \nto identify potentially relevant studies.\nFull-text screening and the articles that pass the \ninitial screening.\nReview the full texts to ensure they meet the \neligibility criteria and extract relevant data from the \nselected studies using a standardized data \nextraction form. We will ensure consistency and \naccuracy in data extraction across all reviewers.\nAnd we will address the disagreements between \nreviewers at any stage of the selection process \nthrough discussion.\nthen we will document the reasons for inclusion or \nexclusion of studies at each stage.\nWe will report the selection process in the final \nreview, including the number of studies screened, \nassessed for eligibility, and included in the review. \nData management  The data management will be \nconducted using Covidence, an online software \nplatform designed to streamline the systematic \nreview process. \nReporting results / Analysis of the evidence The \nresults of the scoping review will be reported in a \nPRISMA flow diagram that will detail the number of \nrecords identified, screened, and included. We will \npresent a table summarizing the characteristics of \nthe included studies, we will present thematic \nanalysis results, identifying key themes and \ncategories related to the impact of Endometriosis \non daily life and functioning. Then we will adress \ngaps and areas needing further investigation. \nDiscussion and summary. \nLanguage restriction No language restriction. \nCountry(ies) involved Israel. \nKeywords Functional activities, women’s health, \nquality of life. \nContributions of each author \nAuthor 1 - Sewar Khatib - first author - will conduct \nthe literature search, search strategy, screen titles \nand abstracts, review full-text articles, extract data, \ndraft the manuscript, and manage the overall \nproject.\nEmail: sewar94@outlook.com\nAuthor 2 - Batya Engel -Yeger - PhD supervisor & \nauthor - Will provide guidance on the search \nstrategy, offer feedback on the manuscript drafts, \nensure the overall quality and rigor of the scoping \nreview, and contribute to the professional writing of \nthe manuscript.\nEmail: bengel@univ.haifa.ac.il\nAuthor 3 - Haya Hassan - Will assist in screening \ntitles and abstracts, reviewing full-text articles, and \nextracting data using Covidence, and will work \ncollaboratively with the authors throughout the \nprocess. As a gynecology intern, will also provide \nprofessional insights into the clinical aspects of \nendometriosis.\nEmail: haya.hassan237@gmail.com\nAuthor 4 - Ari Reiss - As a senior gynecologist, \noffers expert professional insights, particularly on \nthe clinical aspects of endometriosis, and reviews \nthe manuscript to ensure its accuracy.\nEmail: arirei@clalit.org.il\nINPLASY 3Khatib et al. INPLASY protocol 202470101. doi:10.37766/inplasy2024.7.0101\nKhatib et al. INPLASY protocol 202470101. doi:10.37766/inplasy2024.7.0101 Downloaded from https://inplasy.com/inplasy-2024-7-0101/","source_license":"CC0","license_restricted":false}