{"paper_id":"83c83b45-b443-4b3c-a723-088e0f5f6522","body_text":"Journal article\nDiagnostic accuracy of Cancer Antigen 125 (CA125) for endometriosis in symptomatic women: a multi-center study\n- Abstract:\n-\nStudy Objective: To assess the diagnostic accuracy of serum Cancer Antigen 125 (CA 125) ≥ 30 units/milliliter (u/ml) for diagnosing endometriosis in symptomatic women.\nStudy Design: Prospective observational cohort study including patients with symptoms of pelvic pain or subfertility undergoing elective diagnostic laparoscopy at two tertiary referral hospitals. We excluded patients suspected to have other gynecological pathology. We evaluated the accuracy of serum CA 125 (index test) with histologically confirmed endometriosis (reference standard).\nMain Results: Fifty-eight consecutive women recruited between October 2013 to March 2015. Women with endometriosis had a higher CA 125 level than those without endometriosis (mean 54.7 +/−71.6 vs 16.2 +/− 8.0). The specificity of CA 125 ≥ 30 u/ml was 96% (95% CI 81.7–99.9%) and sensitivity was 57% (95% CI 37.4–74.5%). The positive likelihood ratio for the histological presence of endometriosis with a CA 125 ≥ 30 u/ml was 15.8 (95% CI 2.3-112) providing a post-test probability of 94% (95% CI 71% − 99%) in women with pelvic pain or subfertility. The area under the curve, 0.85 (95% CI 0.74–0.96) indicates high test accuracy.\nConclusions: CA 125 ≥ 30 u/ml is highly predictive of endometriosis in women with symptoms of pain and/or subfertility. CA 125 should be considered as a rule-in test for expediting the diagnosis and management of endometriosis, CA 125 < 30 u/ml is, however, unable to rule out endometriosis.\n- Publication status:\n- Published\n- Peer review status:\n- Peer reviewed\nActions\nAccess Document\n- Files:\n-\n-\n(Preview, Accepted manuscript, pdf, 212.6KB, Terms of use)\n-\n- Publisher copy:\n- 10.1016/j.ejogrb.2016.12.002\nAuthors\n- Publisher:\n- Elsevier\n- Journal:\n- European Journal of Obstetrics & Gynecology and Reproductive Biology More from this journal\n- Volume:\n- 210\n- Pages:\n- 102-107\n- Publication date:\n- 2016-12-05\n- Acceptance date:\n- 2016-12-03\n- DOI:\n- ISSN:\n-\n0301-2115\n- Keywords:\n- Pubs id:\n-\npubs:664098\n- UUID:\n-\nuuid:146c195b-4e92-436e-b7b5-6c2e438943b5\n- Local pid:\n-\npubs:664098\n- Source identifiers:\n-\n664098\n- Deposit date:\n-\n2016-12-07\n- ARK identifier:\nTerms of use\n- Copyright holder:\n- © 2016 Elsevier Ireland Ltd All rights reserved\n- Copyright date:\n- 2016\n- Notes:\n- This is the author accepted manuscript following peer review version of the article. The final version is available online from Elsevier at: 10.1016/j.ejogrb.2016.12.002\nIf you are the owner of this record, you can report an update to it here: Report update to this record","source_license":"CC0","license_restricted":false}