{"paper_id":"8242530e-9ca9-4d05-8be4-10f55ea6a961","body_text":"Gastric outlet obstruction is characterised by a mechanical blockage impairing gastric emptying, leading to symptoms such as nausea, vomiting, abdominal pain and significant weight loss [ 1 ] . It is typically caused by malignancies, peptic ulcer disease or Crohn’s disease, but rare causes such as gastric endometriosis must also be considered [ 2 , 3 ] .\nEndometriosis, a chronic oestrogen-driven inflammatory disorder, typically involves pelvic organs but can rarely affect extrapelvic sites, including the gastrointestinal tract [ 4 ] . Gastric involvement is exceptionally rare and presents a diagnostic challenge due to its submucosal location. This report describes a unique presentation of gastric endometriosis causing gastric outlet obstruction, highlighting the diagnostic limitations of standard biopsies and discussing alternative diagnostic and therapeutic approaches.\n\nA 37-year-old female was referred to the gastroenterology clinic in August 2016 with a 2.5-month history of recurrent postprandial vomiting and significant weight loss of 25.4 kg. Her medical history included a subtotal colectomy in 2014 for slow transit constipation and a total abdominal hysterectomy with bilateral salpingo-oophorectomy in 2003 for endometriosis. Her current medications included oestradiol, lansoprazole, metoclopramide, oxybutynin and paracetamol. Oestradiol was prescribed for hormone replacement therapy following the hysterectomy.\nOn physical examination, the patient appeared cachectic. Abdominal examination revealed a well-healed surgical scar, epigastric tenderness and a vague, non-tender palpable mass in the same area. Routine blood tests were within normal limits, including haemoglobin, C-reactive protein (CRP), and renal and liver function tests.\nGiven the clinical suspicion of gastrointestinal stromal tumour (GIST) or malignancy, the patient was referred to a multidisciplinary team in Liverpool. She was readmitted with severe vomiting and initiated on parenteral nutrition. Due to progressive worsening of symptoms, a Whipple’s resection was performed. Histopathological analysis of the resected specimen unexpectedly confirmed gastric endometriosis.\nGiven the diagnosis of gastric endometriosis, the patient was referred to a gynaecologist for further evaluation of her hormone replacement therapy (HRT) regimen. Adjustments to her HRT were considered to reduce the risk of further endometriotic growth.\n\nEndometriosis is characterised by the presence of endometrial-like tissue outside the uterus, typically involving pelvic organs. Gastrointestinal involvement occurs in approximately 5–12% of cases, most commonly affecting the recto-sigmoid colon [ 5 ] . Gastric endometriosis is extremely rare and presents diagnostic difficulties due to its non-specific symptoms and submucosal location [ 6 ] .\nThe presence of negative biopsy results despite imaging evidence of a significant lesion ( Fig. 1 ) highlights the limitations of standard endoscopic biopsy in diagnosing submucosal conditions. Alternative diagnostic approaches, such as endoscopic ultrasound-guided fine-needle aspiration, laparoscopic biopsy or MRI should be considered in similar cases before resorting to major surgery [ 7 , 8 ] . Studies indicate that endoscopic ultrasound-guided fine-needle aspiration has higher sensitivity in diagnosing submucosal lesions compared to standard biopsy techniques [ 9 ] .\nSurgical resection remains the gold standard for both diagnosis and treatment in such cases. The presence of a large, obstructive mass on imaging, combined with pathological lymph node enhancement, raised strong concerns for malignancy or GIST, justifying the surgical approach. Given the oestrogen-dependent nature of endometriosis, a trial of medical therapy such as GnRH agonists, aromatase inhibitors or progestins could have been considered before surgery [ 10 ] . However, in this case, the severity of gastric obstruction symptoms necessitated urgent surgical intervention; due to the severity of gastric outlet obstruction, urgent surgical intervention was required in this case. Postoperative management should include hormonal therapy to suppress residual endometriosis and prevent recurrence. In this case, the patient was referred to a gynaecologist for adjustment HRT to reduce the risk of endometriotic growth.\nThis case underscores the importance of maintaining a high index of suspicion for endometriosis in women of reproductive age presenting with unexplained gastrointestinal symptoms, especially when initial investigations are inconclusive. Early consideration of endometriosis can lead to more timely diagnosis and management, ultimately improving patient outcomes.","source_license":"CC0","license_restricted":false}