{"paper_id":"7ef2f241-958f-4a60-9a33-849f1140a312","body_text":"ECR 2011 / C-1137\nThe follow-up of uterine fibroids treated with HIFU: role of DWI and Dynamic contrast-study MRI\nCongress:\nECR 2011\nPoster Number:\nC-1137\nType:\nScientific Exhibit\nKeywords:\nTreatment effects, MR-Diffusion/Perfusion, MR, Pelvis, Interventional non-vascular, Genital / Reproductive system female, Ablation procedures, Neoplasia\nAuthors:\nV. Zampa, V. Vallini, S. Ortori, F. Porcelli, C. Bartolozzi; Pisa/IT\nDOI:\n10.1594/ecr2011/C-1137\nPurpose\nTo evaluate the role of MRI:\ndiffusion-weighted imaging (DWI)\nDynamic contrast-study\nin assessing the response of uterine fibroids to high intensity focused ultrasound (HIFU) treatment.\nMethods and Materials\nFrom December 2008 to February 2010:\n8 patients (mean age,\n48 years,\nage range 46-52) with symptomatic uterine fibroids free of other pelvic pathology that required surgical intervention\nall patients underwent HIFU\npatients underwent MRI before and 6 months after treatment\nMAGNETIC RESONANCE IMAGING (MRI):\nmultiplanar capacity and excellent soft tissue contrast resolution reflecting pathology\nImaging protocol:\n1.5-T MRI scanner and a multi-phased array coil (cardiac,\n8 channels)\nT2-weighted FSE in the sagittal,\naxial; coronal planes when needed\nDynamic-contrast study (FSPGR)\nDW imaging (b value=...\nResults\nSize before treatment:\n- Range : 5,2 cm to 15 cm\n- Mean : 7.8 cm\nSymptom presentation of 8 patients:\n- abdominal pain,\nmenorrhagia,\ndysmenorrheal\nThe mean ADC value of fibroids before treatment was:\n- 1,10 e-9\n- range 0,42-1,40 e-9\nThe mean ADC value of fibroids after treatment increased andwas:\n- 1.73 e-9\n- range1,60-2,00 e-9\nMedian reduction in tumor size as a percentage of initial tumor volume at 6 months after HIFU treatment was of 65%\nMean fibroid enhancement before treatment was:...\nConclusion\nHIFU ablation appears to be an effective and safe treatment in reducing uterine fibroids volume.\nBoth dynamic studyand DWI may serve as imaging tools to assess treatment response.\nIn spite of the expected reduction of ADC values related to coagulative necrosis,\nwe observed an increase of ADC values.\nThis data should be confirmed in a larger study group and can be a matter of speculation in understanding the cellular effect of HIFU.\nFurther studies are needed to understand the reliability of DWI and,\nparticularly,\nif...\nReferences\n[1].O.\nKilickesmez,\net al.\nQuantitative Diffusion-Weighted Magnetic Resonance Imaging of Noral and Diseased Uterine Zones.\nActa Radiol 2009(3)\n[2].\nSala E,\net al.\nThe role of dynamic contrast-enhanced and diffusion weighted magnetic resonance imaging in the female pelvis.\nEur J Radiol (2010),\ndoi:10.1016/j.ejrad.2010.01.026\n[3].\nMITSUYOSHI I,\net al.\nBLOOD FLOW OCCLUSION VIA ULTRASOUND IMAGE-GUIDED HIGHINTENSITY FOCUSED ULTRASOUND AND ITS EFFECT ON TISSUE PERFUSION.\nUltrasound in Med.\n& Biol.,\nVol.\n33,\nNo.\n3,\npp.\n452–459,\n2007\n[4].\nJ E KENNEDY,\net al.\nHigh intensity focused ultrasound:...\nPersonal Information\nDr Virna Zampa,\nDr Valentina Vallini\nDiagnostic and Interventional Radiology\nDepartment of Oncology,\nTransplants and Advanced Technologies in Medicine\nUniversity of Pisa\nvia Paradisa 2,\n56100 Pisa\nemail: [email protected],\n[email protected]","source_license":"CC0","license_restricted":false}