{"paper_id":"7ddb7478-be45-4130-8104-01c9715ec081","body_text":"Abstract\nObjectives\nEndometriosis has been widely examined from a biomedical perspective, but its cultural and ethnic dimensions have received far less attention. The aim of this study is not to provide nationally representative prevalence estimates or prevalence figures, but rather to examine associations and differences in Perceived Life Course Impact (PLCI) and social support among women diagnosed with endometriosis across ethnic groups.\nDesign\nA cross-sectional study was conducted among 747 Israeli women aged 18–50 years, including 535 Jewish (267 with endometriosis, 268 controls) and 212 Arab (58 with endometriosis, 154 controls) women. Participants completed validated questionnaires assessing PLCI (intimate relationships, education, employment), social support, social negativity, and perceived mental health. Analyses of covariance and hierarchical regression models were used to examine ethnic and diagnostic group differences, controlling for demographic and health-related covariates.\nResults\nWomen with endometriosis (regardless of ethnicity) reported significantly higher PLCI in all life domains, poorer mental health, lower social support, and higher social negativity compared with controls (p < .001). Arab women reported higher PLCI regarding education than Jewish women, and better social interaction patterns were reported by Jewish than Arab women., Jewish women with endometriosis reported worse mental health and higher pain levels than their Arab counterparts. Regression models showed that, for the whole sample, social negativity was the strongest social predictor of PLCI, with social support and menstrual pain joining it for the most part. Social negativity was the strongest predictor of PLCI, among women with endometriosis as well, with social support, menstrual pain, and driving time to the health care clinic, joining it for the most part.\nConclusion\nEndometriosis imposes a substantial life-course burden among women across cultural groups; the ways this burden is experienced and interpreted are shaped by ethnicity, culture, and social environment. Our findings highlight the need for culturally sensitive interventions that address both clinical symptoms and social and cultural determinants of health.\nSimilar content being viewed by others\nAbbreviations\n- PLCI:\n-\nPerceived life course impact\n- HT:\n-\nHormonal therapy\n- HMO:\n-\nHealth maintenance organization\nFunding\nThe authors did not receive any specific funding from public, commercial, or not-for-profit agencies for this research.\nAuthor information\nAuthors and Affiliations\nCorresponding author\nEthics declarations\nEthics approval and consent to participate\nThis study used a cross-sectional design, collecting data through an online panel rather than in a hospital or clinical setting. The study was conducted in accordance with the ethical principles of the Declaration of Helsinki. Ethical approval was obtained from the Institutional Review Board (IRB) of Max Stern Yezreel Valley College (approval no. YVC EMEK 2024-36). All participants provided informed consent prior to participation.\nConsent for publication\nNot applicable.\nCompeting interests\nThe authors declare no competing interests.\nAdditional information\nPublisher’s note\nSpringer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.\nSupplementary Information\nBelow is the link to the electronic supplementary material.\nRights and permissions\nOpen Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.\nAbout this article\nCite this article\nZarecki, C., Satran, C., Kaldawy, A. et al. Cultural pathways to health inequity: perceived life course impact of endometriosis among Jewish and Arab women in Israel. Int J Equity Health (2026). https://doi.org/10.1186/s12939-026-03038-z\nReceived:\nAccepted:\nPublished:\nDOI: https://doi.org/10.1186/s12939-026-03038-z","source_license":"CC0","license_restricted":false}