{"paper_id":"7dd93cf6-4f5d-4f49-9f23-cb81bab5cf0a","body_text":"Published June 15, 2026\n| Version v1\nConference paper\nOpen\nTHE ROLE OF HORMONAL THERAPY IN THE MANAGEMENT OF ADENOMYOSIS\nAuthors/Creators\n- 1. Assistant Urgench State Medical Institute, Uzbekistan\nDescription\nAdenomyosis is a common estrogen-dependent gynecological disorder characterized by the presence of endometrial glands and stroma within the\nmyometrium. The disease is frequently associated with heavy menstrual bleeding, dysmenorrhea, chronic pelvic pain, infertility, and impaired quality of life. Hormonal therapy has become the cornerstone of conservative management due to its ability to suppress estrogen-dependent proliferation and reduce inflammatory activity within adenomyotic lesions. This review analyzes the role of hormonal therapy in the treatment of adenomyosis, focusing on its mechanisms of action, clinical efficacy, and therapeutic benefits. Current evidence indicates that levonorgestrel-releasing intrauterine systems (LNG-IUS), progestins such as dienogest, gonadotropin-releasing hormone (GnRH) agonists, and combined oral contraceptives effectively control symptoms, reduce uterine volume, and preserve reproductive function. Individualized treatment strategies based on patient age, symptom severity, reproductive goals, and disease extent are essential for achieving optimal outcomes.\nFiles\nIbragimova N 253-256 XXI.pdf\nFiles\n(192.9 kB)\n| Name | Size | Download all |\n|---|---|---|\n|\nmd5:f89942d46055c0e75efb2621c90ac817\n|\n192.9 kB | Preview Download |\nAdditional details\nReferences\n- 1. Chapron, C., Vannuccini, S., Santulli, P., Abrão, M. S., Carmona, F., Fraser, I. S., & Petraglia, F. (2020). Diagnosing adenomyosis: an integrated clinical and imaging approach. Human Reproduction Update, 26(3), 392–411.\n- 2. Ибрагимова Н.Ш. Юсупова М.А. Аденомиоз и репродуктивные исходы // Тиббиётда янги кун. 2 (88) 2026 С 181-184 (14.00.00; №22)\n- 3. Ibragimova N. Sh., Yusupova M. A., Ikramova X. S. Differentiated aproach to the diagnosis of adenomiosis in women of reproductive age // Jurnal: Вестник ТМА № 10 (1) 9,2024 (14.00.00; №13)\n- 4. Ibragimova N. Sh., Yusupova M. A. Fertility and Adenomyosis. Solved and Unresolved Problems //Jurnal: American Journal of Medicine and Medical Sciences 2025, 15(12): 4248-4253 DOI: 10.5923/j.ajmms.20251512.11(14.00.00; №2)\n- 5. Vannuccini, S., Luisi, S., Tosti, C., Sorbi, F., & Petraglia, F. (2018). Role of medical therapy in the management of uterine adenomyosis. Fertility and Sterility, 109(3), 398– 405.","source_license":"CC0","license_restricted":false}