{"paper_id":"7dafbca2-e208-450a-ab80-89695f9e501e","body_text":"Print ISSN: 1021-335X\nOnline ISSN: 1791-2431\nInternational Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.\nInternational Journal of Oncology is an international journal devoted to oncology research and cancer treatment.\nCovers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.\nOncology Reports is an international journal devoted to fundamental and applied research in Oncology.\nExperimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.\nOncology Letters is an international journal devoted to Experimental and Clinical Oncology.\nExplores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.\nInternational journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.\nMultidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.\nOpen-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.\nPublishes open-access research on using epigenetics to advance understanding and treatment of human disease.\nAn International Open Access Journal Devoted to General Medicine.\nArticle\n- Authors:\n-\nPages: 327-358|Published online on: March 1, 2000https://doi.org/10.3892/or.7.2.327\n- Expand metrics +\nAlthough clear cell carcinoma of the ovary is considered to be a tumor with poor prognosis, the clinical characteristics has not been defined. The aim of this study was to evaluate the response of clear cell carcinoma of the ovary to first and second-line chemotherapy and explore effective chemotherapy. Fifty-three patients with clear cell carcinoma of the ovary were enrolled between 1988 and 1997 at our department. Since taxol was not available in Japan at that time, cisplatin-based combination chemotherapy has been exclusively used as a standard first-line chemotherapy. Retrospective analyses of clinical characteristics and the response to first or second-line chemotherapy were performed. Median age was 52 years (range 27-71 years). Tumors were 34% (18/53) stage I, 19% (5/53) stage II, 38% (20/53) stage III, and 9% (5/53) stage IV. All patients with I or II stage disease had optimal cytoreduction. Out of 25 patients with III or IV stage disease 20% (5/25) had negative residual tumor, 36% (9/25) had <2 cm residual tumor, and 44% (11/25) had >/=2 cm residual tumor. All patients received postoperative platinum-based chemotherapy. Of 23 patients with measurable residual tumor 8.7% (2/23) completely and 13% (3/23) partially responded to first-line chemotherapy consisting of cisplatin, adriamycin and cyclophosphamide (CAP) or cisplatin and cyclophosphamide (CP) by CT scan or second look laparotomy. Presence of endometriosis was 55% (29/53) but was not a prognostic factor. Although overall response rate of ovarian clear cell carcinoma to first-line chemotherapy by CAP or CP was about 22%, EP or EJ consisting of etoposide and cisplatin or carboplatin used as a second-line chemotherapy showed 29% response rate, while CPT-P consisting of CPT-11 and cisplatin showed 40% response rate. Clear cell carcinomas were frequently present at early stage, with association of endometriosis and with poor overall prognosis. Although patients with advanced ovarian clear cell carcinoma seemed to have better response to CPT-P than conventional platinum-based chemotherapy, further studies are required with larger number of patients to draw firm conclusions.\nCopy and paste a formatted citation\nSpandidos Publications style\nKita T, Kikuchi Y, Kudoh K, Takano M, Goto T, Hirata J, Tode T and Nagata I: Exploratory study of effective chemotherapy to clear cell carcinoma of the ovary.. Oncol Rep 7: 327-358, 2000.\nAPA\nKita, T., Kikuchi, Y., Kudoh, K., Takano, M., Goto, T., Hirata, J. ... Nagata, I. (2000). Exploratory study of effective chemotherapy to clear cell carcinoma of the ovary.. Oncology Reports, 7, 327-358. https://doi.org/10.3892/or.7.2.327\nMLA\nKita, T., Kikuchi, Y., Kudoh, K., Takano, M., Goto, T., Hirata, J., Tode, T., Nagata, I.\"Exploratory study of effective chemotherapy to clear cell carcinoma of the ovary.\". Oncology Reports 7.2 (2000): 327-358.\nChicago\nKita, T., Kikuchi, Y., Kudoh, K., Takano, M., Goto, T., Hirata, J., Tode, T., Nagata, I.\"Exploratory study of effective chemotherapy to clear cell carcinoma of the ovary.\". Oncology Reports 7, no. 2 (2000): 327-358. https://doi.org/10.3892/or.7.2.327","source_license":"public-domain-us","license_restricted":false}