{"paper_id":"7b920d09-c079-43ee-84a3-b1c81a6e33bf","body_text":"Abstract\nBackground\nEndometriosis is a risk factor for ovarian cancer. Endometriosis-associated ovarian cancer (EAOC), most commonly clear cell carcinoma, is believed to develop from ovarian endometrial cysts. In this study, we reviewed published cases of EAOC considered to have developed from endometrial cysts, and focused on the observation period.\nMethods\nWe searched for articles published since January 2000 that reported cases of ovarian cancer thought to have originated from endometrial cysts using PubMed, Web of Science, and Ichushi-Web. The period from the start of follow-up of the endometrial cyst to the diagnosis of ovarian cancer was calculated.\nResults\nSeventy-nine cases were identified from 32 articles. The median period from the diagnosis of endometrial cysts to the diagnosis of ovarian cancer was only 36 months. Approximately 75% of cases developed into cancer within 60 months and most cases developed within 120 months.\nConclusion\nOur results suggest that clinically detectable cysts subsequently diagnosed as ovarian cancer might already have contained cancer cells. Therefore, the mechanism of EAOC development needs to be re-examined and appropriate management guidelines need to be developed.\nSimilar content being viewed by others\nReferences\nAnglesio MS, Yong PJ (2017) Endometriosis-associated ovarian cancers. Clin Obstet Gynecol 60:711–727\nVercellini P, Vigano P, Somigliana E et al (2014) Endometriosis: pathogenesis and treatment. Nat Rev Endocrinol 10:261–275\nBrinton LA, Sakoda LC, Sherman ME et al (2005) Relationship of benign gynecologic diseases to subsequent risk of ovarian and uterine tumors. 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Adv Obstet Gynecol 71:237–246\nFunding\nThis study was supported in part by the Japan Society for the Promotion of Science (JSPS) KAKENHI Grant number 18H02947 (Grant-in-Aid for Scientific Research B for Noriomi Matsumura).\nAuthor information\nAuthors and Affiliations\nCorresponding author\nEthics declarations\nConflict of interest\nThe authors declare that they have no conflict of interest.\nEthical approval\nThis article does not contain any studies with human participants or animals performed by any of the authors.\nInformed consent\nThis study was exempt from informed consent because it was a literature review of previously published studies.\nAdditional information\nPublisher's Note\nSpringer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.\nAbout this article\nCite this article\nMurakami, K., Kotani, Y., Shiro, R. et al. Endometriosis-associated ovarian cancer occurs early during follow-up of endometrial cysts. Int J Clin Oncol 25, 51–58 (2020). https://doi.org/10.1007/s10147-019-01536-5\nReceived:\nAccepted:\nPublished:\nVersion of record:\nIssue date:\nDOI: https://doi.org/10.1007/s10147-019-01536-5","source_license":"CC0","license_restricted":false}