{"paper_id":"755d33dc-4f8c-4d5c-a466-b9d5bb0ae075","body_text":"Abstract\nEndotoxin aggression is involved in the pathogenesis of chronic inflammatory gynecological diseases and primary and secondary female infertility. A significant (13-to 15-fold) increase in the lipopolysaccharide concentration in the blood serum is not associated with a rise in the body temperature or an increase in the titers of antibodies against Re glycolipid, which suggests chronic endotoxin aggression and endotoxin tolerance. Supplementing the conventional scheme of treatment with an antiendotoxin component increases the treatment efficiency, considerably decreases the concentration of bacterial lipopolysaccharides in the blood flow, and increases the antiendotoxin immunity. All this indicates the involvement of endotoxin aggression in the pathogenesis of the diseases under study.\nSimilar content being viewed by others\nReferences\nSmetnik, V.P. and Tomilovich, L.G., Neoperativnaya ginekologiya (rukovodstro dlya vrachei) (Nonsurgical Gynecology: A Handbook for Physicians), Moscow, 2003.\nYakovlev, M.Yu., Endotoxin Shock, Kazan. Med. Zh., 1987, no. 3, p. 207.\nAkhmina, N.I., Perinatal Health Protection of Disease-Predisposed Children, Extended Abstract of Doctoral (Med.) Dissertation, Moscow, 2000.\nYakovlev, M.Yu., The Role of Intestinal Microflora and Insufficiency of the Hepatic Barrier Function in Development of Endotoxinemia and Inflammation, Kazan. Med. Zh., 1988, no. 5, p. 353.\nYakovlev, M.Yu., “Endotoxin Aggression” as a Predisease, or a Universal Pathogenetic Factor of Human and Animal Diseases, Usp. Sovr. Biol., 2003, vol. 123, no. 1, p. 31.\nUrazaev, R.A., Krupnik, A.N., and Yakovlev, M.Yu., Endotoxinemia during Early Adaptation of Newborns and Their Mothers, Kazan. Med. Zh., 1992, no. 2, p. 114.\nLazareva, S.I., The Role of Endotoxinemia in Arising of Antiphospholipid Syndrome in Infants Born by Mothers with Cardiovascular Diseases, Extended Abstract of Cand. Sci. (Med.) Dissertation, Moscow, 2002.\nTabolin, V.A., Bel’chik, Yu,F., Chabaidze, Zh.L., and Yakovlev, M.Yu., Parameters of the Antiendotoxin Immunity in Healthy and Infected Newborns, Int. J. Immunorehabilit., 2000, vol. 2, no. 1, p. 133.\nAnikhovskaya, I.A., Vyshegurov, Ya.Kh., Usov, I.A., and Yakovlev, M.Yu., Bifidobacteria as a Means of Prevention or Treatment of Endotoxin Aggression in Patients with Chronic Diseases during Remission or Exacerbation, Fiziol. Chel., 2004, vol. 30, no. 6, p. 125 [Hum. Physiol. (Engl. Transl.), 2004, vol. 30, no. 6, p. 732].\nAleksandrov, M.T., Evstigneev, A.P., Eliseenko, V.I., et al., Metodicheskie rekomendatsii po klinicheskomu primeneniyu poluprovodnikovykh, dvukhkanal’nykh lazernykh terapevticheskikh apparatov na arsenide galliya (Methodical Recommendations on Clinical Use of Semiconductor Double-Channel Laser Therapeutic Devices Based on Gallium Arsenide), Kaluga, 1999.\nZinkevich, O.D., Anikhovskaya, I.A., Yakovlev, M.Yu., et al., The Method for Determination of Endotoxin Activity (Alternatives), RF Patent. 2 093 825, 2002.\nUrazaev, R.A., Yakovlev, M.Yu., Anikhovskaya, I.A., et al., The Method for Assessment of the Body’s Resistance (“SOIS-IFA”), RF Patent 2 011 993, 1994.\nLikhoded, V.G., Yakovlev, M.Yu., Apollonin, A.V., et al., The method for Assessment of Antiendotoxin Immunity (“LPS-Test-IFA”), RF Patent no. 2088936, 1997.\nLikhoded, V.G., Anikhovskaya, I.A., Apollonin, A.V., et al., The Fc-Dependent Binding of Endotoxin from Gram-Negative Bacteria by Human Blood Polymorphonuclears, Mikrobiologiya, 1996, no. 2, p. 76.\nAnikhovskaya, I.A., The Detection of Risk Groups, Choice of the Examination Scheme, and Assessment of Treatment Efficiency by Antiendotoxin Immunity Parameters, Extended Abstract of Cand. Sci. (Med.) Dissertation, Moscow, 2001.\nYakovlev, M.Yu., Elements of the Endotoxin Theory of Human Physiology and Pathology, Fiziol. Chel., 2003, vol. 29, no. 4, p. 98. [Hum. Physiol. (Engl. Transl.), 2003, vol. 29, no. 4, p. 476].\nMedzhitov, R. and Dzhanevei, Ch., Inborn Immunity, Kazan. Med. Zh., 2004, no. 3, p. 161.\nYakovlev, M.Yu., System Endotoxinemia in Human Physiology and Pathology, Extended Abstract of Doctoral (Med.) Dissertation, Moscow, 1993.\nAuthor information\nAuthors and Affiliations\nAdditional information\nOriginal Russian Text © G.G. Enukidze, I.A. Anikhovskaya, A.A. Marachev, M.Yu. Yakovlev, 2006, published in Fiziologiya Cheloveka, 2006, Vol. 32, No. 3, pp. 117–123.\nRights and permissions\nAbout this article\nCite this article\nEnukidze, G.G., Anikhovskaya, I.A., Marachev, A.A. et al. Endotoxin aggression in the pathogenesis of chronic inflammatory diseases of small pelvis organs and infertility, or an antiendotoxin approach to their treatment. Hum Physiol 32, 351–356 (2006). https://doi.org/10.1134/S0362119706030169\nReceived:\nIssue date:\nDOI: https://doi.org/10.1134/S0362119706030169","source_license":"CC0","license_restricted":false}