{"paper_id":"74f4080e-0dbc-41c3-84d4-36d6430d6def","body_text":"(99% vs 80%, p<0.001). Median follow-up time was 1232\n(1087–1352) days. The primary outcome occurred in 14 of\n116 patients (12%) in the prevention clinic and 49 of 237\n(21%) in the standard clinic (Log-Rank p=0.04). Cerebrovas-\ncular disease and multivessel coronary artery disease were\nindependent predictors for MACE after adjusting for other\npredictors. Attending the prevention clinic was associated with\nreduced MACE (HR 0.53, p=0.04) after adjusting for other\npredictors.\nConclusion There was improved use of new guideline-recom-\nmended treatments in the prevention clinic compared to\nstandard clinics, including lipid-lowering medications, diabetes\ntreatments and long-term dual antithrombotic therapy . This\nwas associated with a 47% lower rate of cardiovascular events\nover a 3-year period.\n7-013 EXPLORING THE CAUSAL RELEVANCE OF GENETICALLY\nPREDICTED ENDOMETRIOSIS ON CARDIAC STRUCTURE,\nFUNCTION AND CARDIOVASCULAR OUTCOMES: A\nENDELIAN RANDOMISATION STUDY\n1J u nY uC h e n , 2Alessandra Maria Ardissino, 3Ophelia Millar, 4Joanna Girling, 1,5,\n*Maddalena Ardissino,3,*Fu Siong Ng. 1National Heart and Lung Institute, Imperial College\nLondon, London, UK ; 2University College London Institute of Cardiovascular Science,\nLondon, UK; 3Royal Berkshire Hospital, Royal Berkshire NHS Trust, Reading, UK; 4Obstetrics\nand Gynaecology, West Middlesex University Hospital, Chelsea and Westminster Hospital\nNHS Foundation Trust, London, UK; 5British Heart Foundation Cardiovascular Epidemiology\nUnit, Department of Public Health and Primary Care, University of Cambridge, Cambridge,\nUK;\n*Senior authors with equal contribution\n10.1136/heartjnl-2025-BCS.209\nIntroduction Endometriosis is a chronic condition affecting 5 –\n10% of women of reproductive age, characterised by ectopic\nendometrial tissue. Although its symptoms, such as chronic\npain, anxiety , and depression, are well-documented, the disea-\nse's complex pathophysiology and its association with cardio-\nvascular disease (CVD) remain unclear. Possible theories\ninclude hormonal changes and release of pro-inflammatory\nmediators leading to systemic inflammation. Cohort studies\nhave shown a potential link, but findings remain inconsistent.\nIn addition, a major limitation to causal inference in observa-\ntional studies is the potential for bias and residual\nconfounding.\nMethods Using Mendelian randomisation (MR), we investigate\nthe causal relationship between genetically predicted endome-\ntriosis and CVD, using data from a genome-wide association\nstudy . Sex-specific, uncorrelated ( r\n2 < 0.05) single nucleotide\npolymorphisms associated with each exposure at genome-wide\nsignificance ( P <5×1 0 /C08) were selected as instrumental var-\niants. Instrumental variables were extracted from a GWAS\nmeta-analysis on 60,674 endometriosis cases and 701,926 con-\ntrols which identified multiple genetic risk loci associated with\nendometriosis. For the primary analysis, inverse-variance\nweighted MR was used to examine associations with CVD\noutcomes, including atrial fibrillation, heart failure, ischaemic\nstroke and coronary artery disease, as well as cardiac magnetic\nresonance (CMR) measures of cardiac structure and function.\nResults No significant association was found between geneti-\ncally predicted endometriosis and coronary artery disease\n(OR=1.00, 95%CI 0.93 to 1.07, p=0.933), heart failure\n(OR=1.00, 95%CI 0.94 to 1.05, p=0.920), ischaemic stroke\n(OR=0.97, 95%CI 0.91 to 1.03, p=0.342), and atrial fibrilla-\ntion (OR=1.06, 95%CI 1.00 to 1.12, p=0.059), as well as\nCMR measures of cardiac structure and function in the left\nand right heart. Genetically predicted endometriosis was not\nassociated with aorta measurements including proximal pulmo-\nnary artery diameter and ascending aorta diameter.\nSensitivity analyses indicated potential pleiotropic effects\nbetween genetically predicted endometriosis and ascending\naorta diameter (MR-Egger intercept test p=0.03, MR-Egger\nb=0.15 [0.08 to 0.21], p=0.04). Further potential direction\npleiotropy was seen between genetically predicted endometrio-\nsis and proximal pulmonary artery diameter (MR-Egger inter-\ncept test p=0.021, MR-Egger b=0.13 [0.07 to 0.19],\np=0.05).\nThe minimum relative risk increase that we had 80%\npower to detect was 5.3% for AF, 11.5% for CAD, 3.9% for\nHF and 7.1% for ischaemic stroke.\nConclusion MR analyses do not identify any direct evidence\nto support a causal role of genetically predicted endometriosis\non CVD or measures of adverse cardiac structure and func-\ntion. There was a trend toward an association of genetically\npredicted endometriosis with higher risk of AF. Further\nresearch is warranted when larger data sources become\navailable.\nAbstract 7-013 Figure 1 Mendelian randomisation estimates for the\neffects of genetically predicted endometriosis on cardiovascular disease\nand cardiac magnetic resonance measures of cardiac structure and\nfunction\nCI=confidence interval, LA max=left atrium maximum volume,\nLATEF=left atrium total emptying fraction, LVSV=left ventricular stroke\nvolume, LVEF=left ventricular ejection fraction, LVEDV=left ventricular\nend-diastolic volume, LVESV=left ventricular end-systolic volume, PA/\nAo=ratio of the pulmonary artery diameter to the ascending aortic\ndiameter, RA FAC=right atrium fractional area change, RA max=right\natrium maximum volume, RA min=right atrium minimum volume,\nRVEDV=right ventricular end-diastolic volume, RVEF=right ventricular\nejection fraction, RVESV=right ventricular end-diastolic volume,\nRVSV=right ventricular stroke volume, Prox PA diameter=proximal\npulmonary artery diameter, PA root diameter=pulmonary artery root\ndiameter.\nAbstracts\nA214 Heart 2025;111(Suppl 3):A1 –A308\nProtected by copyright, including for uses related to text and data mining, AI training, and similar technologies. \n. by guest on May 26, 2026 http://heart.bmj.com/Downloaded from 13 August 2025. 10.1136/heartjnl-2025-BCS.209 on Heart: first published as","source_license":"CC0","license_restricted":false}