{"paper_id":"745622eb-a90c-4e27-9449-533a0ef6f210","body_text":"Abstract\nThe aim of this study was to verify to what extent danazol alters cell-mediated immunity. To this end, cell-mediated immunity was studied in 10 infertile patients with endometriosis and in 10 normal controls. Nonspecific parameters studied included serum SIL-2R, IL-6 and IL-1a levels. We also investigated the effect of treatment with Danazol on the levels of SIL-2R, IL-6 and IL-1a in women with endometriosis. Blood SIL-2R, IL-6 and IL-1a levels were measured in endometriotic women before treatment, during the last fifteen days of a 6-months course of Danazol and three months after treatment. Only one blood sample was taken from 10 women without endometriosis. SIL-2R, IL-6 and IL-1a levels were higher in women with endometriosis before treatment compared with controls. Administration of the drug significantly reduced the levels of SIL-2R (P<0.001), IL-6 (P<0.05) and IL-1a (P<0.01). Our findings suggest that endometriosis is a condition which induces a rise in interleukin levels. Danazol also appears significantly to reduce endometriosis — associated autoimmune abnormalities.\nSimilar content being viewed by others\nReferences\nAmerican Fertility Society (1985) Revised American Fertility Society, Classification of Endometriosis. Fertil Steril 43:351–356\nBadawy SZ, Cuenca V, Stitzel A et al (1984) Autoimmune phenomena in infertile patients with endometriosis. Obstet Gynecol 63:271–275\nBadawy SZ, Cuenca V, Kaufman L, et al (1989) The regulation of immunoglobulins peoduction by B cells in patients with endometriosis. Fertil Steril 51:770–773\nBayshave KD (1985) Cancer drug targeting. Clin Radiol 36:545–549\nButtram VC, Reiter RC, Ward S (1985) Treatment of endometriosis with Danazol: Report of a 6-year prospective study. Fertil Steril 43:353–360\nCimino G, Avvisati G, Amadori S, et al (1982) High serum interleukin-2 levels in patients with monoclonal gammopathy of underermined significance (MGUS) and multiple myeloma. Nouv Rev Fr Hematol 41:329–332\nDinarello CA (1985) An update on human interleukin-1: from molecular biology to clinical relevance. J Clin Immunol 5:287–290\nDmowski WP, Radwanska E (1984) Endometriosis and infertility. Acta Obstet Gynecol Scand (Suppl) 123:73–75\nDmowski WP, Steel RW, Baker GF (1981) Deficient cellular immunity in endometriosis. Am J Obstet Gynecol 141:377–381\nFakin H, Baggett B, Holtz G, et al. (1987) Interleukin 1: a possible role in the infertility associated with endometriosis. Fertil Steril 47:213–217\nFalkoff RJ, Muraguchi A, Hong JX, et al (1983) The effects of inerleukin-1 on human B-cell activation and proliferation. J Immunol 131:801–805\nGleicher N, EI-Roeiy A, Confino E, et al (1987) Autoantibodies in reproductive failure: I. Is endometriosis and autoimmune disease. Obstet Gynecol 70:115–119\nGrossman CJ (1985) Interactions between the gonadal steroids and the immune system. Science 227:257–261\nHaney AF, Muscato JJ, Weinberg JB (1981) Peritoneal fluid cell population in infertility patients. Fertil Steril 35:696–699\nHaney AF, Misukonis MA, Weinberg JB (1983) Macrophages and infertility. Oviductal macrophages as potential mediators of infertility. Fertil Steril 39:310–315\nKishimoto T, Hirano T (1988) Molecular regulation of the B lymphocyte response. Ann Rev Immunol 6:485–489\nMizel B (1982) Interleukin-1 and T-cell activation. Immunol Rev 63:51–55\nOsawa H, Josimovic-Alesevic O, Diamantstein T (1986) Interleukin 2 receptors are released by cells in vitro and in vivo. Eur Immunol 16:467–469\nRossi V, Breviario F, Ghezzi P (1985) Interleukin-1 induces prostacylin in vascular cells. Science 229:174–177\nSteele RW, Dmowski WP, Marmer DJ (1984) Immunologic aspects of human endometriosis. Am J Reprod Immunol 6:33–36\nSthoeger ZM, Chiorazz N, Lahita G (1981) Regulation of the immune response by sex hormones. I. In vitro effects of estradiol and testosterone on pokeweed mitogen-induced human B cell differentiation. J Immunol 141:91–95\nSuginami H, Yano K, Watanabe K (1986) A factor inhibiting ovum capture by the oviductal fimbrial present in endometriosis peritoneal fluid. Fertil Steril 46:1140–1146\nWeed JC, Arguembourg PC (1989) Endometriosis. Can it produce an autoimmune response resulting infertility. Clin Obstet Gynecol 23:885–889\nAuthor information\nAuthors and Affiliations\nRights and permissions\nAbout this article\nCite this article\nKoumantakis, E., Matalliotakis, I., Neonaki, M. et al. Soluble serum interleukin-2 receptor, interleukin-6 and interleukin-1a in patients with endometriosis and in controls. Arch Gynecol Obstet 255, 107–112 (1994). https://doi.org/10.1007/BF02390936\nReceived:\nAccepted:\nIssue date:\nDOI: https://doi.org/10.1007/BF02390936","source_license":"public-domain-us","license_restricted":false}