{"paper_id":"72fb17e0-3b95-4334-af53-b8fe03a1c870","body_text":"Abstract\nPurpose\nTo determine the impact of pelvic inflammation caused by tubo-ovarian abscess (TOA) on ovarian response to stimulation.\nMethods\nThis retrospective longitudinal cohort analysis that was carried out in a tertiary university-affiliated medical center included 15 women with TOA during in vitro fertilization (IVF) cycles. The ovarian response to stimulation and the pregnancy rate were compared in two subsequent cycles, the initial IVF cycle that was complicated by TOA after oocyte retrieval (first treatment cycle) and the following IVF treatment (second treatment cycle) that occurred within a period of a year from the first cycle.\nResults\nThe mean number of retrieved oocytes was significantly higher in the first IVF cycle compared to the second cycle (8.1 ± 3.2 vs. 5.4 ± 2.5, P = .003], corresponding to a 30% reduction in ovarian response to gonadotropin stimulation. Fertilization rates were significantly lower in the second cycle (4.1 ± 2.9 vs. 2.9 ± 1.7, P = .015). Twelve women (80%) reached embryo transfer in the first cycle compared to 14 women (93.3%) in the second cycle. The mean number of transferred embryos was similar between the two cycles. There were no clinical pregnancies following the first cycle, and only one patient (6.6%) had a clinical pregnancy in the second treatment cycle.\nConclusions\nTOA following fertility treatment has a detrimental effect on ovarian function. The pregnancy rate in the immediate period following TOA is poor. Current data for recommending the deferral of fertility treatment following a TOA episode are insufficient, calling for more studies to address these issues.\nSimilar content being viewed by others\nReferences\nSorbye IK, Jerve F, Staff AC (2005) Reduction in hospitalized women with pelvic inflammatory disease in Oslo over the past decade. 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IL: manuscript writing/editing and data analysis. AM: protocol/project development and manuscript writing/editing. FA: manuscript writing/editing. AC: protocol/project development, manuscript writing/editing, and data analysis.\nCorresponding author\nEthics declarations\nConflict of interest\nAll the authors report no conflict of interest and that this research was non-funded.\nAdditional information\nPublisher's Note\nSpringer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.\nRights and permissions\nAbout this article\nCite this article\nFouks, Y., Azem, F., Many, A. et al. Fertility outcomes in patients with tubo-ovarian abscesses after an oocyte retrieval: a longitudinal cohort analysis. Arch Gynecol Obstet 300, 763–769 (2019). https://doi.org/10.1007/s00404-019-05230-9\nReceived:\nAccepted:\nPublished:\nVersion of record:\nIssue date:\nDOI: https://doi.org/10.1007/s00404-019-05230-9","source_license":"CC0","license_restricted":false}