{"paper_id":"7192ecf7-bc43-4530-aaa7-04b640e7ae75","body_text":"Abstract\nObjective\nTo show the efficacy of anti-tumor necrosis factor therapy (etanercept) for treating endometriosis in an experimental model.\nDesign\nA randomized, placebo-controlled, blinded study using rat endometriosis model.\nSetting\nExperimental research center of Ankara Education and Research Hospital.\nAnimal(s)\nTwenty-two Wistar female rats.\nIntervention(s)\nAfter peritoneal implantation of endometrial tissue, rats were randomized to two equal intervention groups: control and etanercept-treated groups. After measuring implant volume, blood and peritoneal fluid samples were obtained. Vehicle treatments of 2 mL saline to rats in control and 0.4 mg/kg etanercept SC once weekly were administered in treatment group. Four weeks later, a third laparotomy was performed to remeasure implant volumes, blood, and peritoneal fluid samples.\nMain outcome measure(s)\nTo compare spherical volume, peritoneal fluid and serum levels of VEGF, IL-6, and TNF-α between groups.\nResult(s)\nThere was a significant difference in spherical volume between control [131.0 (60.3–501.2)] and treatment groups [72.8 (31.2–149.6)] (p < 0.025). In etanercept-treated group, a significant difference was found between peritoneal fluid and serum levels of VEGF, IL-6, and TNF-α (p < 0.01).\nConclusion(s)\nThese results indicate that etanercept was found to effectively reduce the development of endometriosis.\nSimilar content being viewed by others\nAbbreviations\n- VEGF:\n-\nVascular endothelial growth factor\n- IL-6:\n-\nInterleukin-6\n- TNF-α:\n-\nTumor necrosis factor-α\nReferences\nOlive DL, Schwarts LB (1993) Endometriosis. 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Prog Clin Biol Res 323:49–60\nConflict of interest statement\nThe authors declare that they have no conflict of interest.\nAuthor information\nAuthors and Affiliations\nCorresponding author\nRights and permissions\nAbout this article\nCite this article\nZulfikaroglu, E., Kılıc, S., Islimye, M. et al. Efficacy of anti-tumor necrosis factor therapy on endometriosis in an experimental rat model. Arch Gynecol Obstet 283, 799–804 (2011). https://doi.org/10.1007/s00404-010-1434-0\nReceived:\nAccepted:\nPublished:\nIssue date:\nDOI: https://doi.org/10.1007/s00404-010-1434-0","source_license":"CC0","license_restricted":false}