{"paper_id":"70d188a6-d125-4e9d-b942-e84c27941987","body_text":"Abstract\nDysfunctional uttering bleeding (DUB) is an abnormal uterine bleeding in the absence of organic cause. It is usually a painless, excessive and irregular endometrial bleeding that may be prolonged, and it is not attributable to any underlying structural or systemic disease. The etiology DUB arises out of continuing maturation of the hypothalamus, such that the eventual establishment of normal pulsatile gonadotropin release leads to normal menstrual cycle control.\nDUB is usually seen during adolescence. In about 95% of cases DUB is due to the late maturation of the hypothalamic–pituitary–ovarian axis.\nThe evaluation of DUB cases includes a detailed family and personal history as well as a careful gynecological examination, including visualization of the cervix, even in virgin young girls (vaginoscopy), laboratory studies: hematocrit, hemospherin, and others, pelvic ultrasonography, radiological imaging procedures, and rarely hysteroscopy or/and curretage. Endocrinological tests are not always necessary.\nThe disease is classified as mild, moderate, or severe. In mild DUB cases the use of combined oral contraceptives is occasionally indicated as well as a careful follow-up. In cases of moderate degree the use of the new generation 17β-estradiol or the cyclic use of progestagenic compounds is the treatment of choice. Cyclic oral progestogens are administered for the same 10 days every month to prevent the action of unopposed estrogens and stabilize the endometrium.\nAccess this chapter\nTax calculation will be finalised at checkout\nPurchases are for personal use only\nSimilar content being viewed by others\nReferences\nDeligeoroglou E, Tsimaris P (2010) Menstrual disturbances in puberty. Best Pract Res Clin Obstet Gynaecol 24(2):157–171\nFraser IS, Sungurtekin U (2000) Defining menstrual disturbances. In: Maclean A, O’Brien PMS (eds) Study group on menstrual disorders. Royal College of Obstetricians and Gynecologist, London, pp 141–152\nDeligeoroglou E, Karountzos V, Creatsas G (2013) Abnormal uterine bleeding and dysfunctional uterine bleeding in pediatric and adolescent gynecology. Gynecol Endocrinol 29(1):74–78\nFerenczy A (2003) Pathophysiology of endometrial bleeding. Maturitas 45(1):1–14\nTalib HJ, Coupey SM (2012) Excessive uterine bleeding. 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Cochrane Database Syst Rev 9, CD001895. pub3, doi: 10.1002/14651858\nOlive DL (2002) Role of progesterone antagonists and new selective progesterone receptor modulators in reproductive health. Obstet Gynecol Surv 57(11 Suppl 4):S55–S63\nAuthor information\nAuthors and Affiliations\nCorresponding author\nEditor information\nEditors and Affiliations\nRights and permissions\nCopyright information\n© 2014 Springer International Publishing Switzerland\nAbout this chapter\nCite this chapter\nCreatsas, M., Creatsas, G.K. (2014). Dysfunctional Uterine Bleeding During Adolescence. In: Genazzani, A.R., Brincat, M. (eds) Frontiers in Gynecological Endocrinology. ISGE Series. Springer, Cham. https://doi.org/10.1007/978-3-319-03494-2_2\nDownload citation\nDOI: https://doi.org/10.1007/978-3-319-03494-2_2\nPublisher Name: Springer, Cham\nPrint ISBN: 978-3-319-03493-5\nOnline ISBN: 978-3-319-03494-2\neBook Packages: MedicineMedicine (R0)\nKeywords\n- Luteinizing Hormone\n- Immune Thrombocytopenic Purpura\n- Endometrial Thickness\n- Premature Ovarian Failure\n- Endometrial Hyperplasia\nThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.","source_license":"CC0","license_restricted":false}