{"paper_id":"6f84ddf1-be0a-4a61-9d6a-b6da8cce255a","body_text":"We performed a comparative study of the cytotoxic effect of endocannabinoid N-arachidonoyl dopamine (AA-DA) on cultured stromal cells of ectopic and eutopic endometrium. It was found that AA-DA in the concentration range of 1-20 μM produces more selective cytotoxic effect on the stromal cells of the ectopic endometrium due to interaction with cannabinoid type 1 receptor. In concentrations below 1 μM, AA-DA stimulated the proliferation of stromal cells of the eutopic endometrium and did not affect the division of ectopic endometrium cells. This effect was realized due to its interaction with cannabinoid type 2 receptor.\nSimilar content being viewed by others\nReferences\nEndometriosis: Diagnosis, Treatment and Rehabilitation. Federal Clinical Recommendations. Moscow, 2013. Russian.\nAshba AM, Akimov MG, Gretskaya NM, Bezuglov VV. N-acyl dopamines induce cell death in PC12 cell line via induction of nitric oxide generation and oxidative stress. Doklady Biochem. Biophysics. 2016;467(1):81-84.\nBobrov MY, Lyzhin AA, Andrianova EL, Gretskaya NM, Zinchenko GN, Frumkina LE, Khaspekov LG, Bezuglov VV. Antioxidant and neuroprotective properties of N-docosahexaenoyl dopamine. Bull. Exp. Biol. Med. 2006;142(4):425-427.\nChernukha GE, Ilyina LM, Adamyan LV, Pavlovich SV. Deep infiltrating endometriosis: Postoperative recurrences and possible ways of their prevention. Akush. Gin. 2015;(8):39-46. Russian.\nAkimov MG, Ashba AM, Gretskaya NM, Bezuglov VV. Some aspects of the mechanism of cell death induction by the lipids of N-acyl dopamine family in the PC12 cancer cell line. Anticancer Res. 2014;34(10):5797-5800.\nAkimov MG, Gretskaya NM, Zinchenko GN, Bezuglov VV. Cytotoxicity of Endogenous Lipids N-acyl Dopamines and their Possible Metabolic Derivatives for human cancer cell lines of different histological origin. Anticancer Res. 2015;35(5):2657-2661.\nAndrianova EL, Bobrov MY, Gretskaya NM, Zinchenko GN, Fomina-Ageeva EV, Bezuglov VV, Serkov IV. The effects of neurolipins and their synthetic analogues on normal and transformed glial cells. Neurochem. J. 2010;4(1):46-54.\nBerkley KJ, Rapkin AJ, Papka RE. The pains of endometriosis. Science. 2005;308:1587-1589.\nBobrov MY, Lizhin AA, Andrianova EL, Gretskaya NM, Frumkina LE, Khaspekov LG, Bezuglov VV. Antioxidant and neuroprotective properties of N-arachidonoyldopamine. Neurosci. Lett. 2008;431(1):6-11.\nGiudice LC, Kao LC. Endometriosis. Lancet. 2004;364:1789-1799.\nLiu X, Yamada N, Maruyama W, Osawa T. Formation of dopamine adducts derived from brain polyunsaturated fatty acids mechanism for Parkinson disease. J. Biol. Chem. 2008; 283(50):34,887-34,895.\nSchwarz R, Ramer R, Hinz B. Targeting the endocannabinoid system as a potential anticancer approach. Drug Metab. Rev. 2018;50(1):26-53.\nSanchez AM, Cioffi R, Viganò P, Candiani M, Verde R, Piscitelli F, Di Marzo V, Garavaglia E, Panina-Bordignon P. Elevated systemic levels of endocannabinoids and related mediators across the menstrual cycle in women with endometriosis. Reprod. Sci. 2016;23(8):1071-1079.\nAuthor information\nAuthors and Affiliations\nCorresponding author\nAdditional information\nTranslated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 167, No. 1, pp. 46-50, January, 2019\nRights and permissions\nAbout this article\nCite this article\nAshba, A.M., Yushina, M.N., Fedorova-Gogolina, I.A. et al. Selective Action of N-Arachidonoyl Dopamine on Viability and Proliferation of Stromal Cells from Eutopic and Ectopic Endometrium. Bull Exp Biol Med 167, 43–46 (2019). https://doi.org/10.1007/s10517-019-04456-6\nReceived:\nPublished:\nVersion of record:\nIssue date:\nDOI: https://doi.org/10.1007/s10517-019-04456-6","source_license":"CC0","license_restricted":false}