{"paper_id":"6dc177cf-dc4c-4d1c-8642-72d7c748f49c","body_text":"Case Report\nAustin J Endocrinol Diabetes. 2023; 10(1): 1100.\nEndometrioma Detected on Recombinant TSH-Stimulated 18F-FDG-PET/CT\nTamayo-Carabaño D*; Martínez-Diher L\nDepartment of Nuclear Medicine, Universitary Hospital Fundación Jiménez Díaz, Spain\n*Corresponding author: Tamayo-Carabaño Daniella. Department of Nuclear Medicine, Universitary Hospital Fundación Jiménez Díaz, Avda. de los Reyes Católicos, 2, 28040 Madrid, Spain. Tel: +34 915504898 Email: dratamayoc@gmail.com\nReceived: July 17, 2023 Accepted: August 15, 2023 Published: August 22, 2023\nAbstract\nA 43-year-old female patient diagnosed with high-grade follicular thyroid neoplasm in October 2022, treated with total thyroidectomy + left laterocervical lymphadenectomy in February 2023 with stage T4N0M0. A study with 18F-FDG PET/CT stimulated with Recombinant Thyroid-Stimulating Hormone (rTSH) was requested prior to performing ablative treatment with radioactive iodine (131I) on the same day. Two days prior to the PET/CT study, a subcutaneous injection of rTSH (Thyrogen®) was administered, presenting, immediately after, pain in the right iliac fossa that did not subside with anti-inflammatories. The PET/CT image shows tumor remains in the anterior cervical region and a pelvic mass dependent on the right adnexa, not previously known, of a cystic nature, septated with FDG uptake, with an SUVmax of 15,3, which partially compresses the ipsilateral ureter. Treatment with 131I was postponed due to acute abdominal pain and it was decided to take him to the operating room where an oopherectomy + right adnexectomy was performed with an anatomopathological result of endometrioid cystadenoma. Due to structural similarities and cross-reactivity between hormones, and the presence of TSH receptors in endometrioid tissue, we propose that the growth of the tumor lesion in this case was precipitated by rTSH administration.\nKeywords: 18F-FDG PET/CT; Endometrioma; Recombinant thyroid-stimulating hormone; rTSH; TSH receptors; Thyrogen®\nCase Presentation\nWe present the case of a 43-year-old female patient diagnosed with high-grade follicular thyroid neoplasm in October 2022, who was treated with total thyroidectomy and left laterocervical lymphadenectomy in February 2023 with stage T4N0M0. It was decided to perform ablation of thyroid remnants with radioactive iodine (131I), previously requesting an extension study with 18F-FDG PET/CT the same day. The treatment preparation with 131I would be stimulated with Recombinant Thyroid-Stimulating Hormone (rTSH) administered two days before a daily subcutaneous injection of rTSH (Thyrogen®), which would be used to perform the PET/CT study under the same stimulation.\nImmediately after the administration of the injections, the patient began with acute pain in the right iliac fossa that did not subside with anti-inflammatories, and radiated to the ipsilateral flank with positive fist percussion.\nThe acquisition of the 18F-FDG PET/CT study was performed, showing hyper-uptake foci in the anterior cervical region compatible with thyroid remnants; and a pelvic mass of 9 cm in diameter, dependent on the right adnexus, not previously known, of a cystic nature, septated, with FDG uptake, with an SUVmax of 15,3, partially compressing the ipsilateral ureter. These findings are reported as a pelvic mass suggestive of malignancy given its morphometabolic characteristics (Figure 1).\nFigure 1: 18F-FDG PET/CT stimulated with Recombinant Thyroid-Stimulating Hormone (rTSH) showing tumor remains in the anterior cervical region and a pelvic mass dependent on the right adnexa, of a cystic nature, septated with FDG uptake, with an SUVmax of 15,3, which partially compresses the ipsilateral ureter.\nIt was decided to postpone the treatment with 131I due to the acute abdominal pain that the patient presented and the suspicion of synchronous malignant neoplasm in the ovary.\nTwo days later, an oophorectomy + right adnexectomy was performed with an anatomopathological result of endometrioid cystadenoma.\nSubsequently, the patient was treated with 131I, without incident.\nDiscussion\nThyroid-Stimulating Hormone (TSH) is a glycoprotein that has structural similarities to other hormones such as Luteinizing Hormone (LH), Human Chorionic Gonadotropin (hCG), and Follicle-Stimulating Hormone (FSH); likewise, the Thyroid-Stimulating Hormone Receptor (TSH-R) is a glycoprotein that has a common subunit for the aforementioned hormones [1-4].\nExpression of the TSH-R is increased in thyroid cancer, as well as in other malignancies, where the interaction of TSH with its receptor has the potential to stimulate the growth of such neoplasms. It also promotes the production of vascular endothelial growth factor, contributing to angiogenesis [2,3].\nSome studies have shown the expression of TSH-R and thyroid hormone receptors in the endometrium and ovaries of healthy women, with higher expression in ectopic endometrium compared to eutopic endometrium, where TSH stimulates epithelial proliferation, therefore it is believed to be involved in the growth of endometriotic lesions, which has been confirmed in studies with mice. It has even been proposed that a high level of TSH in the blood (>2.5 μIU/ml) could be a non-invasive marker for the diagnosis of endometriosis [1,3-5].\nEndometriosis is a common gynecologic condition that can be visualized on 18F-FDG PET/CT and is useful in differentiating malignant from benign processes. In endometriomas, FDG uptake is generally weak, and a SUVmax of 4.0 has been proposed as a cut-off point to differentiate from their malignant transformation, although they can sometimes simulate malignant lesions. In our case, FDG uptake exceeded this threshold, although the pathology ultimately revealed benignity. This could be related to associated inflammatory changes [6-10].\nExperimental studies showed that TSH stimulates glucose transport and Glut1 expression in cultured thyroid cells. For this reason, it has been proposed to perform the 18F-FDG PET/CT study in differentiated thyroid cancer, previously stimulating with rTSH to increase FDG uptake by malignant cells, although mixed results have been obtained in this regard [11-13].\nConclusion\nDue to all of the above, we propose that in this case the exogenous administration of rTSH may have precipitated the growth of the endometrioma, which was evidenced in our PET/CT study.\nReferences\n- Peyneau M, Kavian N, Chouzenoux S, Nicco C, Jeljeli M, Toullec L, et al. Role of thyroid dysimmunity and thyroid hormones in endometriosis. Proc Natl Acad Sci U S A. June 11, 2019; 116: 11894-9.\n- Vieira IH, Rodrigues D, Paiva I. The mysterious universe of the TSH receptor. Front Endocrinol. July 2022; 13: 944715.\n- Svensson A, Roth B, Kronvall L, Ohlsson B. TSH receptor antibodies (TRAb) – A potential new biomarker for endometriosis. 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