{"paper_id":"6cb7123b-a459-4306-a1bd-1fcac578bef5","body_text":"Print ISSN: 1107-3756\nOnline ISSN: 1791-244X\nInternational Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.\nInternational Journal of Oncology is an international journal devoted to oncology research and cancer treatment.\nCovers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.\nOncology Reports is an international journal devoted to fundamental and applied research in Oncology.\nExperimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.\nOncology Letters is an international journal devoted to Experimental and Clinical Oncology.\nExplores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.\nInternational journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.\nMultidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.\nOpen-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.\nPublishes open-access research on using epigenetics to advance understanding and treatment of human disease.\nAn International Open Access Journal Devoted to General Medicine.\nArticle\n- Authors:\n-\nPages: 909-913|Published online on: June 1, 2007https://doi.org/10.3892/ijmm.19.6.909\n- Expand metrics +\nAngiogenesis is essential for endometrial growth and repair, and disruption of this process may lead to common gynecological disorders, including menorrhagia and endometriosis. We have recently shown that expression of vascular endothelial growth factor (VEGF)-A and its two main receptors, VEGFR-1 and -2, is increased in idiopathic menorrhagia (IM). The aim of this study was to determine the expression of VEGFR-3 in normal and IM endometrium. Endometrial biopsies from 24 patients with IM and 18 healthy and fertile women were used for immunohistochemistry assessments and image analyses of VEGFR-3 and CD34-stained endothelial structures. We found that weak to moderate expression of VEGFR-3 was present in stroma and glands throughout the menstrual cycle without differences between patients and controls. Capillaries expressed VEGFR-3 markedly, whereas arterioles and venules stained moderately to markedly. However, we observed that vascular expression of VEGFR-3 in capillaries was 1.6-fold higher in the IM group than in controls, when assessed as the number of stained capillaries per mm2. There was also a 2.0-fold higher number of arterioles, which were VEGFR-3 positive in the IM group. There was no difference with regard to the menstrual cycle between patients and controls. Thus, human endometrium expresses VEGFR-3, and expression of this receptor is increased in idiopathic menorrhagia. These results indicate that VEGFR-3 may play a role in the abnormal endometrial angiogenesis of IM.\nCopy and paste a formatted citation\nSpandidos Publications style\nMints M, Blomgren B and Palmblad J: Expression of vascular endothelial growth factor receptor-3 in the endometrium in menorrhagia. Int J Mol Med 19: 909-913, 2007.\nAPA\nMints, M., Blomgren, B., & Palmblad, J. (2007). Expression of vascular endothelial growth factor receptor-3 in the endometrium in menorrhagia. International Journal of Molecular Medicine, 19, 909-913. https://doi.org/10.3892/ijmm.19.6.909\nMLA\nMints, M., Blomgren, B., Palmblad, J.\"Expression of vascular endothelial growth factor receptor-3 in the endometrium in menorrhagia\". International Journal of Molecular Medicine 19.6 (2007): 909-913.\nChicago\nMints, M., Blomgren, B., Palmblad, J.\"Expression of vascular endothelial growth factor receptor-3 in the endometrium in menorrhagia\". International Journal of Molecular Medicine 19, no. 6 (2007): 909-913. https://doi.org/10.3892/ijmm.19.6.909","source_license":"CC0","license_restricted":false}