{"paper_id":"6bdc7c42-2756-467b-a1e2-975a7e3851fe","body_text":"Low anterior resection syndrome in patients undergoing bowel segmental resection for rectosigmoid endometriosis: A retrospective long-term follow-up study\nSandra Coll\nDepartment of Obstetrics, Gynecology and Reproduction, Dexeus Mujer. Dexeus University Hospital, Barcelona, Spain\nContribution: Conceptualization, Data curation, Investigation, Writing - original draft, Formal analysis\nSearch for more papers by this authorCorresponding Author\nYannick Hurni\nDepartment of Obstetrics, Gynecology and Reproduction, Dexeus Mujer. Dexeus University Hospital, Barcelona, Spain\nDepartment of Paediatrics, Obstetrics, Gynaecology and Preventive Medicine and Public Health, Faculty of Medicine, Universidad Autónoma de Barcelona, Cerdanyola del Vallès, Barcelona, Spain\nCorrespondence\nYannick Hurni, Department of Obstetrics, Gynecology and Reproduction, Dexeus Mujer. Dexeus University Hospital, Gran Via de Carles III 71-75, 08028 Barcelona, Spain.\nEmail: [email protected]\nContribution: Conceptualization, Methodology, Data curation, Investigation, Formal analysis, Writing - original draft\nSearch for more papers by this authorNuria Barbany-Freixa\nDepartment of Obstetrics, Gynecology and Reproduction, Dexeus Mujer. Dexeus University Hospital, Barcelona, Spain\nContribution: Data curation, Validation, Writing - review & editing\nSearch for more papers by this authorFrancesco La Torre\nDepartment of Obstetrics, Gynecology and Reproduction, Dexeus Mujer. Dexeus University Hospital, Barcelona, Spain\nDivision of Obstetrics and Gynaecology, Department of Experimental and Clinical Biomedical Sciences ‘Mario Serio’, AOU Careggi, University of Florence, Florence, Italy\nContribution: Data curation, Investigation, Writing - review & editing\nSearch for more papers by this authorCarlota Vilarrubí-Jordà\nDepartment of Obstetrics, Gynecology and Reproduction, Dexeus Mujer. Dexeus University Hospital, Barcelona, Spain\nContribution: Data curation, Writing - review & editing, Investigation\nSearch for more papers by this authorMaria Montaño-Serrano\nDepartment of Obstetrics, Gynecology and Reproduction, Dexeus Mujer. Dexeus University Hospital, Barcelona, Spain\nContribution: Investigation, Data curation, Writing - review & editing\nSearch for more papers by this authorLaura Lázaro-García\nQuirúrgica Cirujanos Asociados, Department of General Surgery, Dexeus University Hospital, Barcelona, Spain\nContribution: Investigation, Validation, Writing - review & editing\nSearch for more papers by this authorSilvia Cabrera\nDepartment of Obstetrics, Gynecology and Reproduction, Dexeus Mujer. Dexeus University Hospital, Barcelona, Spain\nContribution: Supervision, Writing - review & editing, Resources\nSearch for more papers by this authorFrancesc Tresserra\nDepartment of Obstetrics, Gynecology and Reproduction, Dexeus Mujer. Dexeus University Hospital, Barcelona, Spain\nContribution: Supervision, Data curation, Writing - review & editing, Resources\nSearch for more papers by this authorPere N. Barri-Soldevila\nDepartment of Obstetrics, Gynecology and Reproduction, Dexeus Mujer. Dexeus University Hospital, Barcelona, Spain\nContribution: Supervision, Conceptualization, Project administration\nSearch for more papers by this authorMaria Antonia Lequerica-Cabello\nQuirúrgica Cirujanos Asociados, Department of General Surgery, Dexeus University Hospital, Barcelona, Spain\nContribution: Conceptualization, Methodology, Investigation, Supervision, Writing - review & editing\nSearch for more papers by this authorSandra Coll\nDepartment of Obstetrics, Gynecology and Reproduction, Dexeus Mujer. Dexeus University Hospital, Barcelona, Spain\nContribution: Conceptualization, Data curation, Investigation, Writing - original draft, Formal analysis\nSearch for more papers by this authorCorresponding Author\nYannick Hurni\nDepartment of Obstetrics, Gynecology and Reproduction, Dexeus Mujer. Dexeus University Hospital, Barcelona, Spain\nDepartment of Paediatrics, Obstetrics, Gynaecology and Preventive Medicine and Public Health, Faculty of Medicine, Universidad Autónoma de Barcelona, Cerdanyola del Vallès, Barcelona, Spain\nCorrespondence\nYannick Hurni, Department of Obstetrics, Gynecology and Reproduction, Dexeus Mujer. Dexeus University Hospital, Gran Via de Carles III 71-75, 08028 Barcelona, Spain.\nEmail: [email protected]\nContribution: Conceptualization, Methodology, Data curation, Investigation, Formal analysis, Writing - original draft\nSearch for more papers by this authorNuria Barbany-Freixa\nDepartment of Obstetrics, Gynecology and Reproduction, Dexeus Mujer. Dexeus University Hospital, Barcelona, Spain\nContribution: Data curation, Validation, Writing - review & editing\nSearch for more papers by this authorFrancesco La Torre\nDepartment of Obstetrics, Gynecology and Reproduction, Dexeus Mujer. Dexeus University Hospital, Barcelona, Spain\nDivision of Obstetrics and Gynaecology, Department of Experimental and Clinical Biomedical Sciences ‘Mario Serio’, AOU Careggi, University of Florence, Florence, Italy\nContribution: Data curation, Investigation, Writing - review & editing\nSearch for more papers by this authorCarlota Vilarrubí-Jordà\nDepartment of Obstetrics, Gynecology and Reproduction, Dexeus Mujer. Dexeus University Hospital, Barcelona, Spain\nContribution: Data curation, Writing - review & editing, Investigation\nSearch for more papers by this authorMaria Montaño-Serrano\nDepartment of Obstetrics, Gynecology and Reproduction, Dexeus Mujer. Dexeus University Hospital, Barcelona, Spain\nContribution: Investigation, Data curation, Writing - review & editing\nSearch for more papers by this authorLaura Lázaro-García\nQuirúrgica Cirujanos Asociados, Department of General Surgery, Dexeus University Hospital, Barcelona, Spain\nContribution: Investigation, Validation, Writing - review & editing\nSearch for more papers by this authorSilvia Cabrera\nDepartment of Obstetrics, Gynecology and Reproduction, Dexeus Mujer. Dexeus University Hospital, Barcelona, Spain\nContribution: Supervision, Writing - review & editing, Resources\nSearch for more papers by this authorFrancesc Tresserra\nDepartment of Obstetrics, Gynecology and Reproduction, Dexeus Mujer. Dexeus University Hospital, Barcelona, Spain\nContribution: Supervision, Data curation, Writing - review & editing, Resources\nSearch for more papers by this authorPere N. Barri-Soldevila\nDepartment of Obstetrics, Gynecology and Reproduction, Dexeus Mujer. Dexeus University Hospital, Barcelona, Spain\nContribution: Supervision, Conceptualization, Project administration\nSearch for more papers by this authorMaria Antonia Lequerica-Cabello\nQuirúrgica Cirujanos Asociados, Department of General Surgery, Dexeus University Hospital, Barcelona, Spain\nContribution: Conceptualization, Methodology, Investigation, Supervision, Writing - review & editing\nSearch for more papers by this authorSandra Coll and Yannick Hurni contributed equally to the manuscript as first authors.\nMaria Antonia Lequerica-Cabello and Pere N. Barri-Soldevila contributed equally as senior authors to this work.\nAbstract\nAim\nThe aim of this work was to evaluate the prevalence of low anterior resection syndrome (LARS) and its long-term evolution following colorectal segmental resection for deep infiltrating endometriosis (DIE) and identify any associated risk factors.\nMethod\nA retrospective observational study was conducted on 124 patients who underwent bowel segmental resection for DIE between 2008 and 2023 at a single tertiary centre. Postoperative rectal function was assessed using the LARS score, and logistic regression analysis was performed to identify independent risk factors for minor/major LARS.\nResults\nLARS was observed in 5.6% of patients, with 1.6% presenting minor LARS and 4.0% major LARS. Logistic regression identified parametrial resection (odds ratio = 6.2, p = 0.04) as an independent risk factor for minor/major LARS. LARS severity remained stable in all cases over a mean follow-up of 6.9 ± 3.7 years.\nConclusion\nAs for previously reported studies, our data highlight a relatively low prevalence of LARS following bowel DIE surgery with stable severity over time. Identifying parametrial resection as an independent risk factor underlines the critical need to recognize this specific aspect of endometriosis surgery, ensuring that it is thoroughly addressed during surgical planning and integrated into patient counselling for proper outcomes and expectations. Prospective studies are needed to confirm these findings, explore additional risk factors and better understand the factors influencing long-term outcomes in this patient population.\nCONFLICT OF INTEREST STATEMENT\nThe authors declare no conflicts of interest.\nDATA AVAILABILITY STATEMENT\nThe data that support the findings of this study are available on request from the corresponding author. 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