{"paper_id":"6b2da1d6-af04-4537-9ad0-8d51a54d1e8e","body_text":"Abstract\nPurpose\nThis study investigated the possibility of K469E (rs5498) and G241R (rs1799969) polymorphisms, in ICAM-1 gene, and G634C (rs1800796), in IL-6 gene, being associated with the occurrence of endometriosis in a sample of Brazilian women.\nMethods\nWe genotyped 200 women (100 in control group and 100 in endometriosis group) by PCR-RFLP technique for G634C, K469E, and G241R polymorphisms.\nResults\nNo significant difference was observed in genotypic frequency between control and endometriosis groups for G634C and K469E polymorphisms (p = 0.61 and p = 0.22, respectively). In addition, no significant difference between stages I-II and III-IV of the disease was found for both SNPs (p = 0.63 and p = 0.24, respectively). All individuals were wild homozygotes for G241R polymorphism.\nConclusion\nThis study suggests that polymorphisms K469E, G241R, and G634C are not associated with increased susceptibility to endometriosis in Brazilian women.\nSimilar content being viewed by others\nReferences\nAghajanpour L, Mashayekhi F, Rajaei F. Intercellular adhesion molecule-1 (ICAM-1) gene polymorphism and endometriosis in northern Iran. Arch Gynecol Obstet. 2011;283(5):1035–9.\nMalutan AM, Drugan T, Costin N, Ciortea R, Bucuri C, Rada MP, et al. Pro-inflammatory cytokines for evaluation of inflammatory status in endometriosis. Cent Eur J Immunol. 2015;40(1):96–102.\nSampson JA. Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavity. Am J Obstet Gynecol. 1927;14:422–69.\nBraun DP, Dmowski WP. Endometriosis: abnormal endometrium and dysfunctional immune response. 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J Soc Gynecol Investig. 2005;12(4):267–71.\nAcknowledgments\nThis study was supported by HC-LIM/FMUSP (LIM-40).\nAuthor information\nAuthors and Affiliations\nCorresponding author\nEthics declarations\nConflict of interest\nThe authors declare they have no conflicts of interests.\nAdditional information\nCapsule\nThis study suggests that polymorphisms K469E, G241R, and G634C are not associated with increased susceptibility to endometriosis in Brazilian women.\nNathalie Zamagni Bessa and Daniela de Oliveira Francisco contributed equally to this work.\nRights and permissions\nAbout this article\nCite this article\nBessa, N.Z., Francisco, D.d.O., Andres, M.d.P. et al. Polymorphisms of ICAM-1 and IL-6 genes related to endometriosis in a sample of Brazilian women. J Assist Reprod Genet 33, 1487–1492 (2016). https://doi.org/10.1007/s10815-016-0796-z\nReceived:\nAccepted:\nPublished:\nIssue date:\nDOI: https://doi.org/10.1007/s10815-016-0796-z","source_license":"CC0","license_restricted":false}