{"paper_id":"6a4ef036-938b-4ea8-9b2d-d565f8da537e","body_text":"Letrozole versus gonadotropins for ovulation induction in patients with endometriosis: a prospective randomized trial\nAbstract\nPurpose: This study aimed to compare the effects of letrozole and gonadotropins for ovulation induction in infertile patients with stage 1-2 endometriosis.\nMaterials and methods: Twenty patients who underwent diagnostic laparoscopy and histologically diagnosed stage 1-2 endometriosis were included in this prospective randomized study. Patients who planned to continue with timed sexual intercourse were randomized into two treatment groups including letrozole (n=10) or gonadotropins (n=10) for minimum three and maximum five treatment cycles.\nResults: Ovulation occurred in 37/45 cycles (82.2%) in the letrozole group and 32/37 cycles (86.4%) in the gonadotropin group, without statistically significant difference (p=0.590). Total number of follicles was significantly higher in gonadotropin group on the day of hCG administration (2.33±0.71 vs. 3.05±0.91, p<0.001). Clinical pregnancy rates both per completed cycles and per patients were similar between two groups (8.1% vs. 9.4%, p=0.850 and 30% vs. 30%, p=1.000; respectively).\nConclusions: Letrozole is well tolerated and cost effective ovulation induction agent in patients with endometriosis and effects of letrozole for ovulation induction were comparable to gonadotropins.\nKeywords\nReferences\n- [1] Greene AD, Lang SA, Kendziorski JA, Sroga-Rios JM, Herzog TJ, Burns KA. Endometriosis: where are we and where are we going? Reproduction. 2016;152(3):R63-https://dx.doi.org/ 10.1530/REP-16-0052.\n- [2] Kiesel L, Sourouni M. Diagnosis of endometriosis in the 21st century. Climacteric. 2019:1-7.https://dx.doi.org/10.1080/13697137.2019.1578743. [Epub ahead of print]\n- [3] Eskenazi B, Warner ML. Epidemiology of endometriosis. Obstetrics &Gynecology Clinics of North America. 1997; 24: 235–258.\n- [4] Guzick DS. Clinical epidemiology of endometriosis and infertility. Obstetrics and Gynecology Clinics of North America 1989; 16: 43–59.\n- [5] Practice Committee of the American Society for Reproductive Medicine. Endometriosis and infertility: a committee opinion. Fertil Steril. 2012;98(3):591-8.\n- [6] Barbieri RL. Endometriosis 1990. Current treatment approaches. Drugs 1990; 39: 502–511.\n- [7] Fisch P, Casper RF, Brown SE et al. Unexplained infertility: evaluation of treatment with clomiphene citrate and human chorionic gonadotropin. Fertil Steril 1989; 51: 828 –833.\n- [8] Ailawadi RK, Jobanputra S, Kataria M, Gurates B, Bulun SE. Treatment of endometriosis and chronic pelvic pain with letrozole and norethindrone acetate: a pilot study. Fertil Steril. 2004; 8: 290-296.\nDetails\nPrimary Language\nEnglish\nSubjects\nObstetrics and Gynaecology\nJournal Section\nResearch Article\nAuthors\nTolga Atakul\n0000-0002-0219-000X\nTürkiye\nGökalp Öner\nThis is me\n0000-0002-6270-4340\nTürkiye\nMahmut Tuncay Özgün\nThis is me\n0000-0003-4946-2268\nTürkiye\nYılmaz Şahin\nThis is me\n0000-0002-3415-8151\nTürkiye\nErcan Mustafa Aygen\nThis is me\n0000-0002-8677-0940\nTürkiye\nPublication Date\nJanuary 21, 2020\nSubmission Date\nApril 2, 2019\nAcceptance Date\nJanuary 3, 2020\nPublished in Issue\nYear 2020 Volume: 13 Number: 1","source_license":"CC0","license_restricted":false}