{"paper_id":"69177650-b319-45a9-8bbf-08a3031a0e08","body_text":"Abstract\nIntroduction\nEndometriosis associated pelvic pain (EAPP) is the most common complaint of patients with endometriosis. Nearly, 70% of females with endometriosis present with EAPP while endometriomas are found in 17–44% of patients.\nMaterial and Methods\nA short-term single centre study was carried out in 56 patients in the age group of 15–35 years with complaints of pain and diagnosed as endometriosis either by imaging studies and/or by laparoscopy was given dienogest 2 mg OD, and effect of treatment was seen as improvement of pain score over a period of 3 months. The effect of dienogest was also seen on size of endometrioma. Patients were followed up at 1 and 3 months.\nResults and Discussion\nOut of 56 patients, 38 (67.8%) patients reported their pain relief within 2–5 days after starting dienogest. Out of 41 patients (73%) who had severe pain at enrollment, only 1 patient (1.79%) complained of severe pain at the end of 1 month with dienogest. Successful reduction in endometriotic cyst size (>50%) was seen in 3 patients (5.3%) at the end of 1 month with dienogest. Out of 56 patients, 41 patients (73.2%) had significant pain relief (>30%) at three months of treatment. At the end of 3 months, seven patients (12.5%) had significant cyst size reduction (>50%) with dienogest. No major side effects were noted.\nConclusion\nDienogest is well tolerated drug for endometriosis showing significant relief of pain. However, it was seen that though endometriomas did not grow during treatment, significant regression was uncommon.\nSimilar content being viewed by others\nReferences\nFoti PV, Farina R, Palmucci S et al. Endometriosis: clinical features, MR imaging findings and pathologic correlation. Insights Imaging. 2018;9(2):149–72.\nAlcázar JL, García-Manero M. 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Dienogest in the treatment of endometriosis: systematic review. Arch Gynecol Obstet. 2015;292(3):523–9.\nTakaesu Y, Nishi H, Kojima J et al. Dienogest compared with gonadotropin-releasing hormone agonist after conservative surgery for endometriosis. J Obstet Gynaecol Res. 2016;42(9):1152–8.\nLee SR, Yi KW, Song JY et al. Efficacy and safety of long-term use of Dienogest in women with ovarian Endometrioma. Reprod Sci. 2018;25(3):341–6.\nFunding\nNone required.\nAuthor information\nAuthors and Affiliations\nCorresponding author\nEthics declarations\nConflict of interest\nThe author declare that they have no conflict of interest.\nEthical Approval\nEthical clearance for the study was taken from hospital ethics committee with number- TP (MD/MS) (97/2018)/IEC/PGIMER/RMLH 1930. (Attached as supplementary file).\nInformed Consent\nWritten informed consent of all study subjects was taken.\nAdditional information\nPublisher's Note\nSpringer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.\nRights and permissions\nAbout this article\nCite this article\nMalik, R., Mann, M.K. Role of Dienogest in Endometriosis in Young Women. J Obstet Gynecol India 71, 522–529 (2021). https://doi.org/10.1007/s13224-021-01483-0\nReceived:\nAccepted:\nPublished:\nVersion of record:\nIssue date:\nDOI: https://doi.org/10.1007/s13224-021-01483-0","source_license":"CC0","license_restricted":false}