{"paper_id":"66da8923-fbc2-4746-9930-cbb38bc8f546","body_text":"Abstract\nPurpose\nTo evaluate the effect of ovarian endometrioma aspiration on IVF/ICSI outcomes.\nMethods\nThe PubMed, EMBASE, Web of Science, China National Knowledge Infrastructure, and Wanfang databases were searched to identify studies related to the treatment of endometrioma up to October 1, 2020, and the data of 1207 patients from 10 studies were analyzed using STATA.\nResults\nThe 10 studies in our analysis included 7 comparing aspiration and surgery and 6 comparing aspiration with no intervention. In the aspiration versus surgery groups, live birth rate [OR 0.97 (95% CI 0.51, 1.85), P = 0.925] and clinical pregnancy rate [OR 1.30 (95% CI 0.95, 1.80), P = 0.105] showed no significant difference between the two groups. Abortion rate [OR 4.26 (95% CI 1.38, 13.08), P = 0.011], the number of oocytes retrieved [mean difference 1.95 (95% CI 0.10, 3.81), P = 0.039], and the estradiol peak on hCG day [mean difference 392.16 (95% CI 230.14, 554.18), P < 0.001] were significantly higher in the aspiration group compared to the surgical group. In the aspiration versus the no intervention group, live birth rate [OR 0.84 (95% CI 0.45, 1.59), P = 0.602] and clinical pregnancy rate [OR 1.25 (95% CI 0.88, 1.77), P = 0.206] were not significantly different between the two groups. The abortion rate [OR 0.31 (95% CI 0.11, 0.88), P = 0.028] and the number of gonadotropin ampoules [mean difference − 3.13 ampoules (95% CI − 4.90, − 1.37), P < 0.001] were significantly lower in the aspiration group compared to the no intervention group.\nConclusion\nCompared with surgical treatment or no intervention treatment, aspiration has less effect on ovarian response, ovarian reserve, and pregnancy outcomes.\nSimilar content being viewed by others\nReferences\nAlborzi S, Sorouri ZZ, Askari E, Poordast T, Chamanara K (2019) The success of various endometrioma treatments in infertility: a systematic review and meta-analysis of prospective studies. Reprod Med Biol 18:312–322. https://doi.org/10.1002/rmb2.12286\nKuivasaari P, Hippelainen M, Anttila M, Heinonen S (2005) Effect of endometriosis on IVF/ICSI outcome: stage III/IV endometriosis worsens cumulative pregnancy and live-born rates. 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Am J Obstet Gynecol 204:61.e1-61.e6. https://doi.org/10.1016/j.ajog.2010.08.040\nAcknowledgements\nThe authors thank all the participants of this study. In addition, we would like to thank Editage (www.editage.cn) for English language editing.\nFunding\nThis study was supported by the National Natural Science Foundation of China (82071617).\nAuthor information\nAuthors and Affiliations\nContributions\nXYG: Data collection, data analysis, manuscript writing/editing. YSZ: Data collection, data analysis, manuscript writing/editing. XXX: Data collection, data analysis, manuscript writing/editing. LY: Protocol development, manuscript writing/editing. SML: Protocol development, manuscript writing/editing. 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Arch Gynecol Obstet 306, 17–28 (2022). https://doi.org/10.1007/s00404-021-06278-2\nReceived:\nAccepted:\nPublished:\nVersion of record:\nIssue date:\nDOI: https://doi.org/10.1007/s00404-021-06278-2","source_license":"CC0","license_restricted":false}