{"paper_id":"66c0c7e0-aed1-4118-aa99-8f3beab1d268","body_text":"Abstract\nEighteen patients affected by laparoscopically confirmed endometriosis were randomly assigned to three different schedules of treatment with gonadotropin-releasing hormone agonist (GnRH-a) (goserelin depot formulation 3.6 mg) every 28 days for 6 months. Six women received the first implant in early follicular phase, 4 in late luteal phase and 8 in 3rd and 17th day from onset of menses. Pretreatment and posttreatment laparoscopic score, performed according to the American Fertility Society scoring system, were compared; a significant reduction in the extent of disease was observed in each group investigated (A and C: p<0.01; B: p<0.05). In each treatment group after the second GnRH-a implant the mean levels of estrone-3-glucuronide (E1-3G), daily measured in early morning urine specimens during the control cycle and the first three months of therapy, were suppressed to menopausal women range. In group B during the 2nd and 3rd month of therapy, the urinary mean levels of EI-3G were significantly lower than in group A and C. In conclusion the different goserelin depot administration schedules gave similar laparoscopic improvement, in spite of the first GnRH-a administration in luteal phase allowed a more marked estrogenic suppression.\nSimilar content being viewed by others\nReferences\nButtram V.C. Jr, Reiter R.C., Ward S. Treatment of endometriosis with danazol: report of a 6-year prospective study. Fertil. Steril. 43: 353, 1985.\nVenturini P.L., Bertoiini S., Marré Brunenghi M.C., Daga A., Fasce V., Marcenaro A., Cimato M., De Cecco L. Endocrine, metabolic, and clinical effects of gestri-none in women with endometriosis. Fertil. Steril. 52: 589, 1989.\nHenzl M.R., Corson S.L., Moghissi K., Buttram V.C., Berqvist C, Jacobson J., For the nafarelin study group. 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Steril. 48: 45, 1987.\nAuthor information\nAuthors and Affiliations\nAdditional information\nPresented in part to: “Giornate Endocrinologiche Pisane”, May 10–11, 1991.\nRights and permissions\nAbout this article\nCite this article\nMagini, A., Pellegrini, S., Tavella, K. et al. Estrogenic suppression by different administration schedules of goserelin depot for treatment of endometriosis. J Endocrinol Invest 16, 775–780 (1993). https://doi.org/10.1007/BF03348925\nReceived:\nAccepted:\nPublished:\nIssue date:\nDOI: https://doi.org/10.1007/BF03348925","source_license":"CC0","license_restricted":false}