{"paper_id":"648d7a44-2a92-44da-bdc5-546f1f534ca1","body_text":"Print ISSN: 1107-3756\nOnline ISSN: 1791-244X\nInternational Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.\nInternational Journal of Oncology is an international journal devoted to oncology research and cancer treatment.\nCovers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.\nOncology Reports is an international journal devoted to fundamental and applied research in Oncology.\nExperimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.\nOncology Letters is an international journal devoted to Experimental and Clinical Oncology.\nExplores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.\nInternational journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.\nMultidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.\nOpen-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.\nPublishes open-access research on using epigenetics to advance understanding and treatment of human disease.\nAn International Open Access Journal Devoted to General Medicine.\nArticle\n- Authors:\n-\nPages: 237-243|Published online on: February 1, 2009https://doi.org/10.3892/ijmm_00000122\n- Expand metrics +\nLocal danazol therapy reduces the signs and symptoms of endometriosis without inhibition of regular ovulation and menstruation and without atrophic changes to the endometrium or vaginal wall. It has been suggested that danazol has possible non-cytotoxic direct actions on eutopic endometrial cells and endometriotic cells. We have investigated the direct effects of danazol on a human endometrial epithelial cell line, HHUA, which is believed to retain many normal intracellular signaling pathways. A thoroughly dissolved solution of danazol enhanced Fas-mediated apoptosis in HHUA cells without inhibiting cell proliferation. Semi-quantitative flow cytometric analysis revealed that danazol did not enhance cell surface expression of Fas antigens. The enhancement of Fas-mediated apoptosis by endometrial cytokines such as EGF, IL-1β and interferon-γ was not additively enhanced by danazol; nor did danazol enhance growth suppression by anticancer drugs such as paclitaxel, carboplatin and 5-fluorouracil. Moreover, danazol did not enhance the irradiation-induced cell growth suppression of radiation-sensitive human cervical squamous cancer ME180 cells. These results indicate that danazol may regulate endometrial epithelial cell proliferation and apoptosis within normal physiology.\nCopy and paste a formatted citation\nSpandidos Publications style\nTanaka T and Umesaki N: Danazol enhances Fas-mediated apoptosis in human endometrial epithelial cells within normal physiology. Int J Mol Med 23: 237-243, 2009.\nAPA\nTanaka, T., & Umesaki, N. (2009). Danazol enhances Fas-mediated apoptosis in human endometrial epithelial cells within normal physiology. International Journal of Molecular Medicine, 23, 237-243. https://doi.org/10.3892/ijmm_00000122\nMLA\nTanaka, T., Umesaki, N.\"Danazol enhances Fas-mediated apoptosis in human endometrial epithelial cells within normal physiology\". International Journal of Molecular Medicine 23.2 (2009): 237-243.\nChicago\nTanaka, T., Umesaki, N.\"Danazol enhances Fas-mediated apoptosis in human endometrial epithelial cells within normal physiology\". International Journal of Molecular Medicine 23, no. 2 (2009): 237-243. https://doi.org/10.3892/ijmm_00000122","source_license":"CC0","license_restricted":false}