{"paper_id":"63b94478-4ebd-4445-9476-a7ce69bc6147","body_text":"子宫内膜异位症患者血清和腹腔液CA-125抗原、血管内皮生长因子水平的相关性研究\nThe correlation research of the levels of CA-125 antigen and vascular endothelial growth factor in serum and peritoneal fluid in patients with endometriosis\n摘要目的 探讨子宫内膜异位症(EMT)患者血清和腹腔液CA-125抗原(CA125)、血管内皮生长因子(VEGF)水平的变化及其与EMT的相关性. 方法 采用酶联免疫吸附测定法(ELISA)测定EMT患者(120例,EMT组)及子宫肌瘤患者(98例,对照组)血清和腹腔液CA125、VEGF水平,并进行比较分析. 结果 EMT组血清CA125、VEGF水平高于对照组[(40.31 ±11.14)kU/L比(24.71±9.19)kU/L,(59.75±6.87)ng/L比(36.38±8.12)ng/L],差异有统计学意义(P<0.05).EMT患者中Ⅰ~Ⅱ期组和Ⅲ~Ⅳ期组血清CA125、VEGF水平比较差异无统计学意义(P>0.05).EMT组腹腔液 CA125、VEGF 水平高于对照组 [(311.46 ±107.29) kU/L比 (158.17 ±55.42) kU/L , (73.28±10.40)ng/L比(40.21±9.84)ng/L],差异有统计学意义(P<0.05).EMT患者中Ⅲ~Ⅳ期组腹腔液CA125、VEGF水平显著高于Ⅰ~Ⅱ期组[(387.41±70.91)kU/L比(308.42±81.21)kU/L, (69.22±7.13)ng/L比(55.44±8.23)ng/L],差异有统计学意义(P<0.05).EMT组血清CA125水平显著低于腹腔液CA125水平,血清VEGF水平显著低于腹腔液VEGF水平[(40.31±11.14)kU/L比(311.46±107.29)kU/L,(59.75±6.87)ng/L比(73.28±10.40)ng/L],差异均有统计学意义(P<0.05).结论 EMT患者血清及腹腔液CA125、VEGF水平与疾病密切相关,腹腔液在监测EMT发生发展中可能较血清有更灵敏及可靠的诊断价值.\n更多相关知识\nabstractsObjective To explore the changes of the levels of CA-125 antigen(CA125) and vascular endothelial growth factor (VEGF) in serum and peritoneal fluid in patients with endometriosis (EMT), and the relationship with EMT. Methods One hundred and twenty patients with EMT (EMT group)and 98 patients with uterine fibroids (control group) were enrolled in this study. The levels of CA125 and VEGF in serum and peritoneal fluid were detected by enzyme linked immunosorbent assay (ELISA), and the results were compared. Results The levels of serum CA125,VEGF in EMT group were significantly higher than those in control group:(40.31±11.14) kU/L vs.(24.71±9.19) kU/L,(59.75±6.87) ng/L vs. (36.38±8.12) ng/L, there were significant differences(P<0.05). The levels of serum CA125,VEGF inⅠ-Ⅱphase andⅢ-Ⅳphase in EMT group had no significant differences ( P>0.05). The levels of peritoneal fluid CA125,VEGF in EMT group were significantly higher than those in control group:(311.46± 107.29) kU/L vs.(158.17± 55.42) kU/L,(73.28 ±10.40) ng/L vs. (40.21 ±9.84) ng/L, there were significant differences (P<0.05). The levels of peritoneal fluid CA125,VEGF in Ⅲ-Ⅳ phase were significantly higher than those in Ⅰ-Ⅱ phase in EMT group:(387.41±70.91) kU/L vs. (308.42±81.21) kU/L, (69.22±7.13) ng/L vs. (55.44±8.23) ng/L, there were significant differences (P<0.05). In EMT group, the levels of CA125 and VEGF in serum were significantly lower those in peritoneal fluid:(40.31±11.14) kU/L vs. (311.46±107.29) kU/L, (59.75±6.87) ng/L vs. (73.28 ±10.40) ng/L, there were significant differences (P<0.05). Conclusions The levels of CA125 and VEGF in serum and peritoneal fluid are closely related to EMT. Peritoneal fluid in monitoring of EMT may be more sensitive and reliable than serum.\nMore相关知识\n- 浏览0\n- 被引5\n- 下载0\n相似文献\n- 中文期刊\n- 外文期刊\n- 学位论文\n- 会议论文","source_license":"CC0","license_restricted":false}