{"paper_id":"6333d67c-12c4-45b1-907f-b49aa5f188ac","body_text":"Abstract\nObjective\nThe goal of this study was to investigate differential expression of the cell cycle signaling proteins p27 and Jun activation domain-binding protein 1 (Jab1) in benign ovarian cysts of patients with endometriosis compared to controls.\nMethods\nOvarian tissues of 26 endometriosis and 28 non-endometriosis patients were used to evaluate expression of p27 and Jab1 by immunohistochemistry.\nResults\nThere are no differences in clinical characteristics between the endometriosis and non-endometriosis group. In the endometriosis group, CD10, Jab1 and p27 were positive in 50, 48.3 and 57.7 % of cases, respectively, compared to 14.3, 17.9 and 50 %, respectively, in the non-endometriosis group. Jab1 and p27 were positive in 69.2 and 84.6 %, respectively, of the definite endometriosis cases.\nConclusions\nThese results demonstrate that Jab1 expression was increased in endometriosis, while p27 expression was similar in the endometriosis and non-endometriosis groups.\nSimilar content being viewed by others\nReferences\nLee W, Park E, Kim D, Kim T, Lee H, Chung S (2011) Expression of p53, p27 and Jab1 protein in epithelial ovarian tumors. Eur J Gynaecol Oncol 33:358–362\nEmberley ED, Niu Y, Leygue E, Tomes L, Gietz RD, Murphy LC et al (2003) Psoriasin interacts with Jab1 and influences breast cancer progression. Cancer Res 63:1954–1961\nBorriello A, Bencivenga D, Criscuolo M, Caldarelli I, Cucciolla V, Tramontano A et al (2011) Targeting p27Kip1 protein: its relevance in the therapy of human cancer. Expert Opin Ther Targets 15:677–693\nMasciullo V, Sgambato A, Pacilio C, Pucci B, Ferrandina G, Palazzo J et al (1999) Frequent loss of expression of the cyclin-dependent kinase inhibitor p27 in epithelial ovarian cancer. Cancer Res 59:3790–3794\nRassidakis GZ, Claret FX, Lai R, Zhang Q, Sarris AH, McDonnell TJ et al (2003) Expression of p27(Kip1) and c-Jun activation binding protein 1 are inversely correlated in systemic anaplastic large cell lymphoma. Clin Cancer Res 9:1121–1128\nKouvaraki MA, Korapati AL, Rassidakis GZ, Tian L, Zhang Q, Chiao P et al (2006) Potential role of Jun activation domain-binding protein 1 as a negative regulator of p27kip1 in pancreatic adenocarcinoma. Cancer Res 66:8581–8589\nJeon JH, Lee KN, Hwang CY, Kwon KS, You KH, Choi I (2005) Tumor suppressor VDUP1 increases p27(kip1) stability by inhibiting JAB1. Cancer Res 65:4485–4489\nSui L, Dong Y, Ohno M, Watanabe Y, Sugimoto K, Tai Y et al (2001) Jab1 expression is associated with inverse expression of p27(kip1) and poor prognosis in epithelial ovarian tumors. Clin Cancer Res 7:4130–4135\nShaulian E, Karin M (2002) AP-1 as a regulator of cell life and death. Nat Cell Biol 4:E131–E136\nBeliard A, Noel A, Foidart JM (2004) Reduction of apoptosis and proliferation in endometriosis. Fertil Steril 82:80–85\nWalter AJ, Hentz JG, Magtibay PM, Cornella JL, Magrina JF (2001) Endometriosis: correlation between histologic and visual findings at laparoscopy. Am J Obstet Gynecol 184:1407–1413\nChu P, Arber DA (2000) Paraffin-Section Detection of CD10 in 505 Nonhematopoietic Neoplasms Frequent Expression in Renal Cell Carcinoma and Endometrial Stromal Sarcoma. Am J Clin Pathol 113:374–382\nSumathi V, McCluggage W (2002) CD10 is useful in demonstrating endometrial stroma at ectopic sites and in confirming a diagnosis of endometriosis. J Clin Pathol 55:391–392\nGroisman GM, Meir A (2003) CD10 is helpful in detecting occult or inconspicuous endometrial stromal cells in cases of presumptive endometriosis. Arch Pathol Lab Med 127:1003–1006\nMcCluggage W, Sumathi V, Maxwell P (2001) CD10 is a sensitive and diagnostically useful immunohistochemical marker of normal endometrial stroma and of endometrial stromal neoplasms. Histopathology 39:273–278\nSchor E, da Silva ID, Sato H, Baracat EC, Girao MJ, de Freitas V (2009) P27Kip1 is down-regulated in the endometrium of women with endometriosis. Fertil Steril 91:682–686\nCamargo-Kosugi CM, da Silva ID, Sato H, D’Amora P, Carvalho CV, Nogueira-de-Souza NC et al (2009) The V109G polymorphism in the p27 gene is associated with endometriosis. Eur J Obstet Gynecol Reprod Biol 145:180–183\nMatsuzaki S, Canis M, Murakami T, Dechelotte P, Bruhat MA, Okamura K (2001) Expression of the cyclin-dependent kinase inhibitor p27Kip1 in eutopic endometrium and peritoneal endometriosis. Fertil Steril 75:956–960\nShiozawa T, Nikaido T, Nakayama K, Lu X, Fujii S (1998) Involvement of cyclin-dependent kinase inhibitor p27Kip1 in growth inhibition of endometrium in the secretory phase and of hyperplastic endometrium treated with progesterone. Mol Hum Reprod 4:899–905\nAcknowledgments\nThis work was supported in part by the Soonchunhyang University Research Fund (20130617). This work was partly supported by Jeil Pharmacy.\nConflict of interest\nThe authors declare no conflicts of interest.\nAuthor information\nAuthors and Affiliations\nCorresponding author\nRights and permissions\nAbout this article\nCite this article\nKim, TH., Lee, HH., Chung, SH. et al. Expression of p27 and Jun activation domain-binding protein 1 in endometriosis. Arch Gynecol Obstet 292, 377–381 (2015). https://doi.org/10.1007/s00404-015-3642-0\nReceived:\nAccepted:\nPublished:\nIssue date:\nDOI: https://doi.org/10.1007/s00404-015-3642-0","source_license":"CC0","license_restricted":false}