{"paper_id":"62a2ed62-2793-4223-9b2d-10903a34ffc3","body_text":"Abstract\nWe studied the effect of ovarian cancer and its chemotherapy on the urinary excretion of prostacyclin (PGI2) and thromboxane A2 (TxA2) hydration and metabolic products. In six patients we measured 6-keto-PGF1 alpha and 2,3-dinor-6-keto-PGF1 alpha (PGI2 products) and thromboxane B2 (TxB2) and 2,3-dinor-TxB2 (TxA2 products) by HPLC followed by radioimmunoassay before, during and after the combined infusion of cisplatin, 4'epi-adriamycin and cyclophosphamide. Before the first cytostatic infusion, the urinary excretion of prostanoids was on average 4.4-5.8 times higher than in patients with ovarian endometriosis (n = 19). The infusion of cytostatics led to a 50-120% rise in the excretion of prostanoids during the first post-infusion 9 hours, but in the subsequent 10 hours their output was 25-45% below the initial value and remained low for at least 2 weeks. Following repetitive courses of cytostatics (2-4 per patient), prostanoid excretion tended to normalise. These data suggest that ovarian cancer is associated with increased production of PGI2 and TxA2, and that cytostatics suppress this production. This may be of biological significance in tumour behaviour and in the effect of cytostatics.\nThis is a preview of subscription content, access via your institution\nAccess options\nSubscribe to this journal\nReceive 24 print issues and online access\n251,40 € per year\nonly 10,48 € per issue\nBuy this article\n- Purchase on SpringerLink\n- Instant access to the full article PDF.\n39,95 €\nPrices may be subject to local taxes which are calculated during checkout\nSimilar content being viewed by others\nAuthor information\nAuthors and Affiliations\nRights and permissions\nAbout this article\nCite this article\nAitokallio-Tallberg, A., Viinikka, L. & Ylikorkala, O. Urinary excretion of prostacyclin and thromboxane degradation products in patients with ovarian malignancy: effect of cytostatic treatment. Br J Cancer 60, 785–788 (1989). https://doi.org/10.1038/bjc.1989.360\nIssue date:\nDOI: https://doi.org/10.1038/bjc.1989.360","source_license":"public-domain-us","license_restricted":false}