{"paper_id":"6083c4b3-c510-4dfb-8b4d-92f797b28cdb","body_text":"Is systemic inflammation associated with reduced ovarian reserve in endometriosis? An investigation of anti-Müllerian hormone and inflammatory markers\nAbstract\nObjective\nTo examine the correlation between levels of anti-Müllerian hormone (AMH)—which serves as an indicator of ovarian reserve—and inflammation markers in women with endometriomas.\nMethods\nThis retrospective investigation involved 91 women with surgically verified endometriomas. Data on demographics, endometriosis features, and serum inflammatory markers were gathered.\nResults\nAge exhibited a negative correlation with AMH levels (r = −0.474, P < 0.001). The monocyte-to-lymphocyte ratio, Systemic Immune-Inflammation Index, and platelet-to-lymphocyte ratio exhibited negative correlations with AMH (r = −0.225, P = 0.032; r = −0.223, P = 0.033; and r = −0.270, P = 0.010, respectively). Age and the platelet-to-lymphocyte ratio were found to be independent predictors of AMH levels.\nConclusions\nSystemic inflammation appears to be an independent predictor and causative factor of diminished ovarian reserve in endometriosis. These findings highlight the necessity for additional studies regarding the influence of inflammation on ovarian reserve and the possible therapeutic ramifications of regulating inflammation in managing endometriosis.\nCONFLICT OF INTEREST STATEMENT\nThe authors have no conflicts of interests.\nDATA AVAILABILITY STATEMENT\nThe data sets used and/or analyzed during the current study are available from the corresponding author on reasonable request.","source_license":"public-domain-us","license_restricted":false}