{"paper_id":"5ebb2bf0-58b9-4a8e-b9da-318bcb3308ae","body_text":"Polyps in the bile duct are rare\n 1 \n 2 \n. Most cases have been treated surgically, and there are few reports of polypectomy without concomitant surgery\n 3 \n 4 \n 5 \n. We report the first case of successful cold polypectomy in the hilar bile duct using a new slim cholangioscope (DRES Slim Scope and CMOS Camera; Japan Lifeline. Co., Ltd, Tokyo, Japan).\nA 66-year-old woman was referred for evaluation of jaundice. Endoscopic retrograde cholangiopancreatography was performed, but the distal bile duct was narrow and a conventional cholangioscope could not be inserted into the bile duct. An inflammatory polyp was diagnosed by biopsy. Contrast-enhanced computed tomography confirmed the absence of blood flow to the polyp (\n Fig. 1 \n). We attempted polypectomy using a new slim cholangioscope (\n Video 1 \n) because the polyp was located in the hepatic hilar and surgery would have been excessive.\nFluoroscopy (\n a ,b \n) and preoperative computed tomography findings (\n c–f \n).\n a \nNarrow distal bile duct.\n b \nA conventional\ncholangioscope could not be inserted into the bile duct.\n c–f \nWe\nconfirmed the absence of blood flow to the polyp.\n c \nThe polyp in\nthe bile duct (blue arrowhead).\n d \nArterial phase.\n e \nPortal phase.\n f \nDelay phase.\nCold polypectomy with a new slim cholangioscope.\nVideo 1\nThe slim cholangioscope was inserted into the bile duct, the polyp was located, and the absence of tumor vessels was confirmed (\n Fig. 2 \n). After removing the slim cholangioscope, the snare (SpyGlass retrieval snare; Boston Scientific, Marlborough, Massachusetts, USA) was advanced over the guidewire to the hepatic hilar. Next, a 5-Fr cytology brush outer sheath was inserted into the bile duct.\nThe polyp on imaging.\n a, b \nFluoroscopy revealed the polyp\n(yellow frame shows enlarged view).\n c \nWe confirmed the absence of\ntumor vessels using the slim cholangioscope.\nA complementary metal oxide semiconductor (CMOS) camera was then passed through the outer sheath to observe the polyp (\n Fig. 3 \n). Finally, we performed cold polypectomy using a snare under direct visualization via the CMOS camera.\nPolypectomy procedure.\n a \nThe snare was inserted into the bile duct over the guidewire.\n b \nA 5-Fr cytology brush outer sheath was inserted into the bile duct while leaving the guidewire in the bile duct.\n c \nThen, the complementary metal oxide semiconductor (CMOS) camera was advanced into the outer sheath and polypectomy was performed under direct visualization.\nAfter endoscopic treatment, the patient was discharged without any adverse events and progressed without recurrence. Stromal tissue similar to endometrial stroma was revealed. Immunostaining was positive for estrogen receptors, leading to a diagnosis of ectopic endometriosis of the bile duct (\n Fig. 4 \n).\nPolypectomy in the hilar biliary duct and histopathological findings.\n a \nFluoroscopic image before endoscopic treatment.\n b \nThe\ndefect in the hilar biliary duct disappeared after endoscopic treatment.\n c \nThe polyp after polypectomy.\n d \nHematoxylin and eosin\nstain.\n e, f \nThe sample was positive for estrogen receptor stain\n(\n e \n) and CD10 (\n f \n). Stromal tissue that\nwas similar to endometrial stroma was observed.\nThe reusable CMOS camera facilitates procedures such as polypectomy. This method also enables the use of an electrochemical snare and represents a new advancement in future biliary treatment strategies.\nEndoscopy_UCTN_Code_TTT_1AR_2AB","source_license":"CC-BY-4.0","license_restricted":false}