{"paper_id":"5dfbe963-3de3-4bad-84bc-b5e1d45270d4","body_text":"Abstract\nExogenous dinitrosyl iron complexes (DNIC) with thiolate ligands as NO and NO+ donors are capable of exerting both regulatory and cytotoxic effects on diverse biological processes similarly to those characteristic of endogenous nitric oxide. Regulatory activity of DNIC (vasodilatory, hypotensive, suppressing thrombosis, increasing erythrocyte elasticity, accelerating skin wound healing, inducing penile erection, etc.) is determined by their capacity of NO and NO+ transfer to biological targets of the latter (heme- and thiol-containing proteins, respectively) due to higher affinity of the proteins for NO and NO+ than that of DNIC. Cytotoxic activity of DNIC is provided by rapid DNIC decomposition under action of iron-chelating compounds, resulting in appearance of NO and NO+ in cells and tissues in high amounts. 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Physicochemistry of dinitrosyl iron complexes with thiolate ligands underlying their beneficial effect in endometriosis. BIOPHYSICS 59, 628–634 (2014). https://doi.org/10.1134/S0006350914040253\nReceived:\nPublished:\nIssue date:\nDOI: https://doi.org/10.1134/S0006350914040253","source_license":"CC0","license_restricted":false}