{"paper_id":"5b0aefde-5d94-4d7e-9ebd-14db63253d77","body_text":"Review: PDF Only\nTherapeutic Uses of Gonadotropin-Releasing Hormone Analogs\n- JANICE L. ANDREYKO\n- LORNA A. MARSHALL\n- DANIEL A. DUMESIC\n- ROBERT B. JAFFE\nObstetrical & Gynecological Survey 42(1):p 1-21, January 1987.\nSince the discovery and synthesis of gonadotropin-releasing hormone (GnRH) in 1971, numerous long-acting agonistic and antagonistic analogs have been synthesized. Agonistic analogs were found to desensitize pituitary GnRH receptors with chronic use, resulting in decreased gonadotropin secretion and a hypogonadal state. These analogs are being investigated as potential contraceptives and in the treatment of several conditions in which decreased gonadal steroid production is desired. Substantial progress has been made in these areas. The purpose of this review is to provide the clinician with data regarding the potential clinical utility of this class of peptides.\nCopyright © Williams & Wilkins 1987. All Rights Reserved.","source_license":"public-domain-us","license_restricted":false}