{"paper_id":"5ac96cc4-8979-4c5e-b5cf-b6b2934cfc29","body_text":"Abstract\nObjective: The objective of this review is to update the current state of knowledge on the role of MMPs in the pathophysiology of endometriosis and discuss the potential utility of treatments that may directly or indirectly target their action in endometriosis.\nResults: In this review we summarize the current state of knowledge on the MMPs and the pathogenesis of endometriosis, discuss the role of the MMPs in endometriosis pathophysiology, summarize current treatments for endometriosis and discuss potential utility of inhibition of MMP action in endometriosis treatment.\nConclusion: Based upon the current state of knowledge, therapeutic approaches targeting MMPs may be useful in mitigating the proliferation and the establishment of the lesions but further patientbased studies are clearly needed.\nKeywords: Endometriosis, matrix metalloproteinase, tissue inhibitor of matrix metalloproteinase, pathophysiology, therapeutic targets, extracellular matrix.","source_license":"CC0","license_restricted":false}