{"paper_id":"59f1c8e2-187a-4538-84f0-be72ed836551","body_text":"Abstract\nPrimary squamous cell carcinoma (SCC) associated with ovarian endometriosis is extremely rare and has a poor prognosis due to insufficient information on the optimal postoperative treatment. Here, we describe the response of this tumor to the administration of paclitaxel–carboplatin. A 45-year-old woman diagnosed with stage IIIc primary SCC of the ovary associated with endometriosis underwent optimal surgery followed by six courses of chemotherapy at 3-week intervals with paclitaxel and carboplatin. She tolerated the chemotherapy well and remained without evidence of disease during first-line chemotherapy. Two months later, she was readmitted with recurrence of a pelvic tumor. Although she was treated with chemotherapy (weekly paclitaxel and chemotherapeutic regimen of irinotecan + mitomycin C), the tumor was resistant to second-line and third-line chemotherapy and she died 15 months after surgery. Paclitaxel–carboplatin administration may be an effective treatment for primary SCC of the ovary but further studies are required to investigate it true efficacy in the treatment of this disease.\nSimilar content being viewed by others\nReferences\nPins MR, Young RH, Daly WJ et al (1996) Primary squamous cell carcinoma of the ovary. Report of 37 cases. Am J Surg Pathol 20:823–833\nPetterson F (1991) Annual report of the results of treatment in gynecological cancer. International Federation of Gynecology and Obstetrics, Stockholm\nMcCoullough K, Floats ER, Falk HC (1946) Epidermoid carcinoma arising in an endometrial cyst of the ovary. Arch Pathol Lab Med 41:335\nLele SB, Piver MS, Barlow JJ et al (1977) Squamous cell carcinoma arising in ovarian endometriosis. Gynecol Oncol 6:290–293\nChen KTK, Weilert M (1982) Squamous cell carcinoma arising in endometriosis. Diagn Gynecol Obstet 4:343\nTetu B, Silva EG, Gershenson DM (1987) Squamous cell carcinoma of the ovary. Arch Pathol Lab Med 111:864–866\nNaresh KN, Ahuja VK, Rao CR et al (1991) Squamous cell carcinoma arising in endometriosis of the ovary. J Clin Pathol 44:958–959\nCampagnutta E, Sopracordevole F, Spolaor L et al (1994) Squamous cell carcinoma in ovarian endometriosis. A case report. J Reprod Med 39:557–560\nEltabbakh GH, Hempling RE, Recio FO et al (1998) Remarkable response of primary squamous cell carcinoma of the ovary to paclitaxel and cisplatin. Obstet Gynecol 91:844–846\nOhtani K, Sakamoto H, Masaoka N et al (2000) A case of rapidly growing ovarian squamous cell carcinoma successfully controlled by weekly paclitaxel–carboplatin administration. Gynecol Oncol 79:515–518\nConflict of interest\nNone.\nAuthor information\nAuthors and Affiliations\nCorresponding author\nAbout this article\nCite this article\nYamakawa, Y., Ushijima, M. & Kato, K. Primary squamous cell carcinoma associated with ovarian endometriosis: a case report and literature review. Int J Clin Oncol 16, 709–713 (2011). https://doi.org/10.1007/s10147-011-0189-3\nReceived:\nAccepted:\nPublished:\nIssue date:\nDOI: https://doi.org/10.1007/s10147-011-0189-3","source_license":"CC0","license_restricted":false}