{"paper_id":"5926d741-1718-4bc7-ae13-3748e1ca7864","body_text":"Abstract\nPurpose\nStudies have suggested that endometriosis may coexist with irritable bowel syndrome (IBS). Using a population-based cohort study, we followed subjects for a 5-year period to identify the risk of IBS after a diagnosis of endometriosis.\nMethods\nThis cohort study used the Taiwan National Health Insurance Database as a source of subjects. A total of 6076 patients with endometriosis from 2000 to 2005 were identified. Their data were compared with those of 30,380 age-matched controls without endometriosis who were randomly selected from the same database. All subjects were tracked for 5 years from the date of cohort entry to identify the risk of IBS. The Cox model was used to evaluate the 5-year event occurrence of IBS.\nResults\nNine hundred twenty-six patients were diagnosed with IBS, including 256 in the case cohort (4.2 %) and 670 in the control cohort (2.2 %). The Kaplan-Meier survival curves demonstrated significantly lower event-free rates in the case cohort than in the control cohort (P = 0.001). After adjusting for urbanization level, monthly income, residential region and comorbidities, the hazard ratio (HR) within 5 years revealed a 1.79-fold (95 % confidence interval [CI] 1.55–2.07) greater risk among the cases than the controls. The HR was higher within the first year of follow-up (HR 1.90, 95 % CI 1.42–2.55) and in those women aged 25–34 years (HR 2.17, 95 % CI 1.61–2.92).\nConclusions\nThe risk of IBS among endometriosis patients persisted over 5 years of follow-up. The association detected in this study might have proceeded through shared risk and pathogenic factors.\nSimilar content being viewed by others\nReferences\nGiudice LC, Kao LC (2004) Endometriosis. Lancet 364(9447):1789–1799\nEskenazi B, Warner ML (1997) Epidemiology of endometriosis. 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Gastroenterology 126(3):693–702\nBarbara G (2011) Editorial: toll-like receptor expression in irritable bowel syndrome: on the alert for a microbial threat? Am J Gastroenterol 106(2):337–339\nAcknowledgments\nThis work was supported by the National Science Council, Taiwan (Grants No. NSC 101-2623-E-010-001-NU and NSC 103-2410-H-264-004). We thank the ELSEVIER for English editing.\nConflict of interest\nThe authors report no conflict of interest.\nAuthor information\nAuthors and Affiliations\nCorresponding authors\nAdditional information\nChen-Yi Wu and Wei-Pin Chang contributed equally to this work.\nRights and permissions\nAbout this article\nCite this article\nWu, CY., Chang, WP., Chang, YH. et al. The risk of irritable bowel syndrome in patients with endometriosis during a 5-year follow-up: a nationwide population-based cohort study. Int J Colorectal Dis 30, 907–912 (2015). https://doi.org/10.1007/s00384-015-2218-6\nAccepted:\nPublished:\nIssue date:\nDOI: https://doi.org/10.1007/s00384-015-2218-6","source_license":"public-domain-us","license_restricted":false}